Published September 19, 2023 | Version v1
Dataset Open

Codeletion of 1p and 19q determines distinct gene methylation and expression profiles in IDH-mutated oligodendroglial tumors _ Dataset

Authors/Creators

  • 1. Complejo Hospitalario Universitario de Toledo

Description

Overall design: Genome-wide DNA methylation profiling of oligodendroglial tumors (OTs) and five non tumoral brain tissue (NTBT) samples. The Illumina Infinium Human DNA methylation 450k Beadchip was used to obtain DNA methylation profiles across approximately 450,000 CpGs in tumoral samples. Samples included 46 OTs and 5 NTBT.

Bisulphite converted DNA from the 51 samples were hybridised to the Illumina Infinium 450k Human Methylation Beadchip

Extracted molecule: genomic DNA

Platform: Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)

Label protocol: Standard Illumina Protocol

Hybridization protocol: bisulphite converted DNA was amplified, fragmented and hybridised to Illumina Infinium Human Methylation 450K Beadchip using standard Illumina protocol

Scan protocol: Arrays were imaged using BeadArray Reader using standard recommended Illumina scanner setting 

Data processing: BeadStudio software v3.2

Data format: IDAT files

Files

20230918_METHYLATION_OLIGO_DATA_Melendez_v1.zip

Files (439.9 MB)

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Additional details

Related works

Is source of
Peer review: 10.1007/s00401-013-1130-9 (DOI)

Subjects

Oligodendroglioma
http://id.nlm.nih.gov/mesh/D009837
DNA methylation
r http://id.nlm.nih.gov/mesh/D019175
Prognosis
http://id.nlm.nih.gov/mesh/D011379
Isocitrate Dehydrogenase
http://id.nlm.nih.gov/mesh/D007521
Genetics
http://id.nlm.nih.gov/mesh/Q000235