CURRENT TRENDS, MODERN SYNTHETIC APPROACH, SAR AND BIOLOGICAL ACTIVITIES OF BENZIMIDAZOLE DERIVATIVES
Authors/Creators
- 1. Assistant Professor, Centurion University of Technology and Management, Gopalpur, Balasore, Odisha, India.
- 2. Associate Professor, MB School of Pharmaceutical Sciences, Mohan Babu University, Sree Sainath Nagar, Tirupati, Andhra Pradesh.
- 3. Tamilnadu Physical Education and Sports University, Chennai.
- 4. Professor Cum Principal, Danteswari College of Pharmacy, Borpadar, Raipur Road, Jagdalpur, Chhattisgarh, C.G.
- 5. Associate Professor, Department of Pharmacy, IIMT College of Medical Sciences, IIMT University, Ganga Nagar, Meerut.
- 6. Professor, Department of Pharmaceutical Analysis, MB School of Pharmaceutical Sciences, Mohan Babu University, (Erstwhile Sree Vidyaniketan College of Pharmacy), Tirupati.
Description
Abstract
Background: Benzimidazole is a heterocyclic compound with a benzene ring fused to an imidazole ring. It is commercially available as a white, odorless, and tasteless powder. O-phenylenediamine and formic acid are condensed to form benzimidazole. The most common benzimidazole substance found in nature is N- riosyldimethylbenzimidazole, which functions as an axial ligand for cobalt in vitamin B12. Aim: The main objective of the review is to explore Current trends, modern synthetic approach, SAR and Biological activities of benzimidazole derivatives. Method and material: All the data were collected from online published article which in indexed in SCOPUS, WOS, and UGC. Result: Benzimidazole derivatives are generally well-tolerated, but they can cause side effects such as nausea, vomiting, and diarrhea. They can also interact with other medications, so it is important to talk to your doctor before taking them. Conclusion: In order to inform the reader on the chemical and pharmacological properties of these compounds, the goal of this article is to provide them a thorough overview of the substituted benzimidazoles.