REVIEW OF MUCOADHESIVE BUCCAL TABLET OF ALOGLIPTIN

In the present project of Alogliptin mucoadhesive buccal tablets were prepared and evaluated. As Alogliptin undergoes extensive first pass metabolism its bioavailability when given through Conventional route is 30% and (80x4) doses. So, in order to improve its bioavailability, to decrease the dosing frequency and to bypass the first pass metabolism the study has been planned to prepare Alogliptin buccal tablets The gift sample of Alogliptin was analyzed by various organoleptic and spectrophotometric methods. The sample of Alogliptin possesses similar color, odor, and taste and texture s given in officials. The melting point of procured sample was analyzed by capillary fusion method and found 180oC. The qualitative solubility of Alogliptin was determined by various solvent systems.

Keywords: Mucoadhesive, Alogliptin, Buccal delivery system.