Published September 7, 2023
| Version v1
Journal article
Open
Redirecting an anti-IL-1β antibody to bind a new, unrelated computationally predicted epitope on hIL-17A
Authors/Creators
- Fischman, Sharon1
- Levin, Itay1
- Rondeau, Jean-Michel2
- Štrajbl, Marek1
- Lehmann, Sylvie2
- Huber, Thomas2
- Nimrod, Guy1
- Cebe, Régis2
- Omer, Dotan1
- Kovarik, Jiri2
- Bernstein, Shmuel1
- Sasson, Yehezkel1
- Demishtein, Alik1
- Shlamkovich, Tomer1
- Bluvshtein, Olga1
- Grossman, Noam1
- Barak-Fuchs, Reut1
- Zhenin, Michael1
- Fastman, Yair1
- Twito, Shir1
- Vana, Tal1
- Zur, Nevet1
- Ofran, Yanay3
- 1. Biolojic Design LTD, Rehovot, Israel
- 2. Novartis Institutes for Biomedical Research, Basel, Switzerland
- 3. The Goodman Faculty of Life Sciences, Nanotechnology Building, Bar Ilan University, Ramat Gan, Israel
Description
HexRf is an algorithm that evaluates the potential of antibodies to bind to new epitopes. Python source code and model parameters as well as an example usage are provided.