THE ROLE OF ESTROGENIC DEFICIENCY IN THE DEVELOPMENT AND PROGRESSION OF GENITAL PROLAPSE

Our results of the study allowed us to establish that the mutant A allele and the A/A genotype of the rs9340799 polymorphism in the estrogen receptor gene ESR1 are associated with an increased risk of developing a severe degree of genital prolapse and can be considered as independent genetic markers that have a pathogenetic contribution to the aggravation of the disease, while the main genotype G/G is a protective marker that prevents the transition of the disease into a severe form.