Published April 1, 2023
| Version 1
Journal article
Open
Lipid-Based Nanocarrier as Bioactive Transporter for Peptide Delivery: A Recent Update
Authors/Creators
- 1. 1Faculty of Pharmacy, Dehradun Institute of Technology University, Dehradun- 248009
- 2. Himalayan Institute of Pharmacy & Research, Rajawala, Dehradun, UK-248007
- 3. Amrapali Institute of Pharmacy and Sciences, Haldwani, Uttarakhand-263139
Description
Lipid-based Nanocarriers are becoming popular nowadays because of their potential application in oral drug delivery systems having advantages like strong compatibility, and low toxicity. The bioactive molecules for nanocarrier drug delivery systems play a role in the promising treatment of diseases like urinary tract infection, dental problems, cancer, etc. To overcome the problem i.e., physical, and chemical unstability, various types of nanocarrier delivery systems that stabilize by using approaches of encapsulation technology are introduced. Lipid nanoparticles are stabilized by adding emulsifiers. The main aim of this article is a detailed discussion of different types of colloidal nanocarrier, advantages, disadvantages, different types of barriers to the delivery of protein and peptides, approaches for enhancing oral bioavailability of protein, and peptides. The eudratec pep technology, peptelligence and eligen technology are the newer technology to overcome the problem that arises in the protein and peptide delivery.
Keywords
Nanocarrier, Fabrication technology, Eudratec pep technology, Peptelligence, Eligen technology.
Notes
Niu Z, Conejos-Sánchez I, Griffin BT, O'Driscoll CM, Alonso MJ. Lipid-based nanocarriers for oral peptide delivery. Advanced Drug Delivery Reviews. 2016; 106:337-354.
2.
Martínez-Ballesta Mc, Gil-Izquierdo Á, García-Viguera C, Domínguez-Perles R. Nanoparticles and controlled delivery for bioactive compounds: Outlining challenges for new "smart-foods" for health. Foods. 2018;7(5).
3.
Vance ME, Kuiken T, Vejerano EP, McGinnis SP, Hochella MF, Hull DR. Nanotechnology in the real world: Redeveloping the nanomaterial consumer products inventory. Beilstein Journal of Nanotechnology. 2015;6(1):1769-1780.
4.
Dmitriy B, Adilkhan Y, Zharylkasyn, Kamila R, Arman S. Peptide-based delivery systems; Medicina (Kaunsas). 2021 Nov; 57(11).
5.
Lin CH, Chen CH, Lin ZC, Fang JY. Recent advances in oral delivery of drugs and bioactive natural products using solid lipid nanoparticles as the carriers. Journal of Food and Drug Analysis. 2017;25(2):219-234.
6.
Choonara BF, Choonara YE, Kumar P, Bijukumar D, du Toit LC, Pillay V. A review of advanced oral drug delivery technologies facilitating the protection and absorption of protein and peptide molecules. Biotechnology Advances. 2014;32(7):1269-1282.
7.
Akolade JO, Oloyede HOB, Onyenekwe PC. Encapsulation in chitosan-based polyelectrolyte complexes enhances antidiabetic activity of curcumin. Journal of Functional Foods. 2017; 35:584-594.
8.
Chen W, Shen Y, Su H, Zheng X. Hispidin derived from Phellinus linteus affords protection against acrylamide-induced oxidative stress in Caco-2 cells. Chemico-Biological Interactions. 2014; 219:83-89.
9.
Chen W, Zhuang J, Li Y, Shen Y, Zheng X. Myricitrin protects against peroxynitrite-mediated DNA damage and cytotoxicity in astrocytes. Food Chemistry. 2013;141(2):927-933.
10.
Hu D, Xu Y, Xie J, Sun C, Zheng X, Chen W. Systematic evaluation of phenolic compounds and protective capacity of a new mulberry cultivar J33 against palmitic acid-induced lipotoxicity using a simulated digestion method. Food Chemistry. 2018; 258:43-50.
11.
Zhang L, Xu Y, Li Y, Bao T, Gowd V, Chen W. Protective property of mulberry digest against oxidative stress – A potential approach to ameliorate dietary acrylamide-induced cytotoxicity. Food Chemistry. 2017; 230:306-315.
12.
Ariyarathna IR, Nedra Karunaratne D. Use of chickpea protein for encapsulation of folate to enhance nutritional potency and stability. Food and Bioproducts Processing. 2015; 95:76-82.
13.
Schwarz C, Mehnert W, Lucks JS, Miiller RH. Solid Lipid Nanoparticles (SLN) for Controlled Drug Delivery. I. Production, Characterization and Sterilization. Vol 30.; 1994.
14.
Èller RHM, Èder KM, Gohla S. Solid Lipid Nanoparticles (SLN) for Controlled Drug Delivery, a Review of the State of the Art. 2000 Jul;50(1):161-77.
15.
Wissing SA, Kayser O, Müller RH. Solid lipid nanoparticles for parenteral drug delivery. Advanced Drug Delivery Reviews. 2004;56(9):1257-1272.
16.
Mehnert W, Mader K. Solid Lipid Nanoparticles Production, Characterization and Applications. Vol 47.; 2001.
17.
Garcia-Fuentes M, Torres D, Alonso MJ. New surface-modified lipid nanoparticles as delivery vehicles for salmon calcitonin. International Journal of Pharmaceutics. 2005;296(1-2):122-132.
18.
cpb.58.1195.
19.
Mehrotra S, Pathak K. Trans labial drug delivery: potential and possibilities. Therapeutic delivery. 2020;11(11):673-676.
20.
Hu FQ, Hong Y, Yuan H. Preparation, and characterization of solid lipid nanoparticles containing peptide. International Journal of Pharmaceutics. 2004;273(1-2):29-35.
21.
McClements DJ. Encapsulation, protection, and delivery of bioactive proteins and peptides using nanoparticle and microparticle systems: A review. Advances in Colloid and Interface Science. 2018;253(2017)
22.
Xu Y, Zheng Y, Wu L, Zhu X, Zhang Z, Huang Y. Novel Solid Lipid Nanoparticle with Endosomal Escape Function for Oral Delivery of Insulin. ACS Applied Materials and Interfaces. 2018;10(11):9315-9324.
23.
Alsulays BB, Anwer MK, Soliman GA, Alshehri SM, Khafagy ES. Impact of penetratin stereochemistry on the oral bioavailability of insulin-loaded solid lipid nanoparticles. International Journal of Nanomedicine. 2019; 14:9127-9138.