Published September 1, 2023 | Version v1
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A COMPREHENSIVE REVIEW ON CANDESARTAN CILEXETIL: PHARMACOLOGICAL, PHARMACEUTICAL AND ANALYTICAL PROFILE

  • 1. 1. Department of Pharmaceutical Analysis, Vignan Pharmacy College, Vadlamudi, Guntur, 522213, Andhra Pradesh, India. 2. Department of Pharmaceutics, Vignan Pharmacy College, Vadlamudi, Guntur, 522213, Andhra Pradesh, India.

Description

Candesartan cilexetil (CAN), a prominent angiotensin II receptor blocker (ARB), has gained significant attention in cardiovascular medicine. This comprehensive review article delves into various facets of CAN, ranging from its pharmacology and pharmacodynamics to drug interactions, contraindications, and adverse reactions. The pharmacological profile of this compound is explored, elucidating its mechanism of action and its role in modulating the renin-angiotensin-aldosterone system. A detailed description of CAN, its formulation, tablet names, brand names, and compositions, is presented in a tabular format for quick reference. A crucial aspect of this review is the discussion of drug interactions, highlighting potential combinations that require caution and vigilant monitoring. Robust analytical techniques are vital for quality control, bioavailability assessment, and bioequivalence studies. Moreover, this article goes beyond clinical aspects by encompassing analytical methods employed in the quantification of CAN. The incorporation of analytical methods provides a comprehensive overview of the scientific methodologies used to measure CAN concentrations in biological samples.

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