Published March 31, 2021
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Fig. 5 in Karanjin
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- 1. Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam, 781039, India
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Fig. 5. Proposed karanjin mediated mechanism: I. Karanjin suppress TNFα production; II. Karanjin inhibits protein tyrosine phosphatase-1β (PTP-1β) which suppresses IRS-1 and activates AMPK and induces GLUT4 translocation; III. Karanjin inhibits degradation of I- κB; IV. Karanjin inhibits NF- κB translocation to nucleus; V. Karanjin suppresses ROS; VI. Induces cell cycle arrest, G2/M arrest and increase in subG1 population; VII. Karanjin induce BAX/BCL-2 ratio by inhibiting BCL-2 expression; VIII. Karanjin induce p53 expression; IX. Karanjin induces drug efflux and metabolism.
Notes
Published as part of Singh, A., Bhatt, G., Gujre, N., Mitra, S., Swaminathan, R., Limaye, A.M. & Rangan, L., 2021, Karanjin, pp. 1-13 in Phytochemistry (112641) 183 on page 10, DOI: 10.1016/j.phytochem.2020.112641, http://zenodo.org/record/8291563
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- Journal article: 10.1016/j.phytochem.2020.112641 (DOI)
- Journal article: urn:lsid:plazi.org:pub:FE01FFB0301D4E22FF98FFEACE5B9C62 (LSID)
- Journal article: http://publication.plazi.org/id/FE01FFB0301D4E22FF98FFEACE5B9C62 (URL)
- Journal article: https://zenodo.org/record/8291563 (URL)