Polycystic Kidney in a Foetus
Authors/Creators
- 1. Department of Anatomy, Maharajah's Institute of Medical Sciences, Nellimarla-536217 (A.P.)
Description
Polycystic kidney disease is one of the life-threatening inherited disorder summated by the development of bilateral or unilateral renal cysts that might lead to renal failure in due course of time. This disorder affects 1 in 1000 live births. A still born male human foetus of 31 weeks gestation was brought from one of the private nursing homes by post graduate students for study of foetal anomalies as part of their project work. During dissection of the foetus, the kidneys were found to be of 8 cms in length and 5.5 cms in width which were almost of the adult size. The kidneys were subjected to histological examination. Microscopic examination revealed scanty cortical areas with glomeruli and proximal convoluted tubules with large cystic cavities at the juxta cortical regions.
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Additional details
References
- 1. Blyth H, Ockenden BG: Polycystic disease of kidneys and liver presenting in childhood. Journal of Medical Genetics, 1971;8(3): 257–284
- 2. Deget F, Rudnik-Schoneborn S, Zerres K: Course of autosomal recessive polycystic kidney disease (ARPKD) in siblings: A clinical comparison of 20 sibships. Clinical Genetics, 1995;47(5): 248–253.
- 3. Qian CN , Knol J, Igarashi P, Lin F, Zylstra U, Teh BT, Williams BO: Cystic Renal Neoplasia following conditional inactivation of Apc in Mouse renal tubular epithelium. The Journal of Biological Chemistry, 2005; 280, (5):3938-3945.
- 4. Sadler TW: System-based Embryology (Chapter 15 - Urogenital system). In: Langman's Medical Embryology (Part 2). 10th Edn; Lippincot Williams & Wilkins, Philadelphia, 2006; pp.233-234.
- 5. Verghese Priya: Polycystic kidney disease, e-Medicine specialities, Pediatrics: General Medicine, 2006; Nov 13: 1-20.
- 6. Zerres K, Mucher G, Becker J, Steinkamm C, RudnikSchoneborn S, Heikkila P, Rapola J, Salonen R, Germino GG, Onuchic L, Somlo S, Avner ED, Harman LA, Stockwin JM, Guay-Woodford LM: Prenatal diagnosis of autosomal recessive polycystic kidney disease (ARPKD): Molecular genetics, clinical experience, and fetal morphology. American Journal of Medical Genetics, 1998; 76(2): 137–144.