People's Journal of Scientific Research
Published December 1, 2011 | Version v1
Journal article Open

Periodontal Disease and Diabetes - A Two Way Street Dual Highway?

Authors/Creators

  • 1. Department of Periodontics, Al Badar Dental College & Hospital, Gulbarga
  • 2. Department of Oral Pathology, S. Nijlingappa Dental College Hospital, Gulbarga,
  • 3. Department of Pedodontics & Preventive Dentistry, People's College of Dental Sciences and Research Centre, Bhopal
  • 4. Department of Oral Medicine and Radiology, Al Badar Dental College & Hospital, Gulbarga

Description

Periodontitis is considered to be the sixth most common complication of diabetes. There is a two way relationship in which periodontal disease has adverse impact on glycemic control and in turn diabetes exaggerates periodontal infection, affecting the overall general health of an individual. In this article we have tried to review the recent research developments and mechanisms by which both diabetes and periodontal disease cause mutual destruction. Our aim of this article is to make aware, both general dental and medical practioner about interrelationship between periodontal disease and diabetes with special emphasis on importance of mutual consultation between the two fraternity, which in turn significantly contributes to general well being of an individual.

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References

  • 1. Atkinson MA, Maclaren NK: What causes diabetes? Scientific American, 1990; 263(1):62-71.
  • 2. Baciü M, Plancak D, Graniü M: CPITN assessment of periodontal disease in diabetic patients. Journal of Periodontology, 1988;59(12):816-822
  • 3. Brown LJ, Löe H: Prevalence, extent, severity and progression of periodontal disease. Periodontology, 2000, 1993; 2(Jun): 57 - 71.
  • 4. Brownlee M, Cerami A: The biochemistry of the complications of diabetes mellitus. Annals Review of Biochemistry, 1981; 50: 385 - 432.
  • 5. Brownlee M: Glycation products and the pathogenesis of diabetic complications. Diabetes care, 1992; 15(12): 1835 - 1843.
  • 6. Brownlee M: Glycosylation and diabetic complications. Diabetes, 1994; 43(6): 836 - 841.
  • 7. Current concepts in management of diabetes type II. Seminar nutrition, 1999; 18: 1-14.
  • 8. Darré L, Vergnes JN, Gourdy P, Sixou M: Efficacy of periodontal treatment on glycemic control in diabetic patient: A Meta analysis of interventional studies. Diabetes & Metabolism, 2008; 34(5): 497-506.
  • 9. Diabetes control and complications trial research group. The diabetes control complications trial (DCCT): Design and methodological considerations for the feasibility phase, 1986;35:530-545.
  • 10. Dumitrescu AL, Inagaki K: Interrelationship between periodontal disease and mortality in CVD, metabolic syndrome & diabetes mellitus. In: Etiology and Pathogenesis of periodontal diseases. Dr Alexandriana L Dumitrescu (Eds.) Ist Edn. Springer – Verlag, Berlin Heidelberg, 2010: 125 – 157.
  • 11. Frantzis TG, Reeve CM, Brown AL(Jr): The ultrastructure of capillary basement membranes in the attached gingiva of diabetic and nondiabetic patients with periodontal disease. Journal of Periodontology,1971;42(7):406 -411.
  • 12. Gibbons RJ, Van Houte J: Bacterial Adherence and the Formation of Dental Plaques. In: Bacterial Adherence. EH Beachey, Eds.; Chapman and Hall London, 1980: 61- 104
  • 13. Grant-Theule DA: Periodontal disease, diabetes, and immune response: a review of current concepts. Journal of western society of periodontology, 1996; 44(3): 69 – 77.
  • 14. Grossi SG, Genco RJ: Periodontal disease and diabetes mellitus, a two way relationship. Annals of Periodontology, 1998; 3(1): 51 – 61.
  • 15. Grossi SG, Skrepcinski FB, DeCaro T, Robertson DC, Ho AW, Dunford RG, Genco RJ: Treatment of periodontal disease in diabetics reduces glycated hemoglobin. Journal of Periodontology, 1997; 68(8): 713 – 719.
  • 16. Iwamoto Y, Nishimura F, Nakalgawa M, Sugimoto H, Shikata K, Makino H, Fukuda T, Tsuji T, Iwamoto M, Murayama Y: The effect of antimicrobial periodontal treatment on circulating tumor necrosis factor-alpha and glycated hemoglobin level in patients with type 2 diabetes. Journal of Periodontology, 2001; 72(6):774- 778.
  • 17. Kirstein M, Aston C, Hintz R, Vlassara H: Receptorspecific induction of insulin-like growth factor I in human monocytes by advanced glycosylation end productmodified proteins. The Journal of Clinical Investigations, 1992; 90(2): 439-446.
  • 18. Krejci CB, Bissada NF: Periodontitis – The risks for its development. General Dentistry, 2000; 48(4): 430 – 436
  • 19. Lalla E, Lamster IB, Drury S, Fu C, Schmidt AM: Hyperglycemia, glycoxidation and receptor for advanced glycation endproducts: potential mechanisms underlying diabetic complications, including diabetesassociated periodontitis. Periodontology 2000, 2000; 23(1): 50–62
  • 20. Ling PR, Bistrian BR, Mendez B, Istfan NW: Effects of systemic infusions of endotoxin, tumor necrosis factor, and interleukin-1 on glucose metabolism in the rat: relationship to endogenous glucose production and peripheral tissue glucose uptake. Metabolism, 1994; 43(3):279-284.
  • 21. Listgarten MA, Ricker FH Jr, Laster L, Shapiro J, Cohen DW: Vascular basement lamina thickness in the normal and inflamed gingiva of diabetics and non-diabetics. Journal of Periodontology 1974; 45(9):676-684.
  • 22. Löe H: Periodontal disease. The sixth complication of diabetes mellitus. Diabetes care, 1993; 16(1):329-334.
  • 23. Madden TE, Herriges B, Boyd L, Laughlin G, Chlodo G , Rosenstein DI: Alterations in HbA1c following minimal or enhanced non-surgical, non antibiotic treatment of gingivitis or mild periodontitis in type 2 diabetic patients: A Pilot trial. The Journal of Contemporary Dental Practice, 2008; 9(5):9-16.
  • 24. Monnier VM, Glomb M, Elgavish A, Seu DR: The mechanism of collagen cross-linking in diabetics. A puzzle nearing resolution. Diabetes, 1996; 45(Suppl 3): S67 – 72.
  • 25. Mariotti A: Dental plaque-induced gingival disease. Annals of Periodontology, 1999; 4(1): 7 - 19.
  • 26. Matthews DC: The relationship between diabetes and periodontal disease. Journal of Canadian Dental Association 2002; 68(3):161-164.
  • 27. Mealey B: Diabetes and periodontal disease. Journal of Periodontology, 1999; 70(8): 935-349
  • 28. Mealey BL, Oates TW: Diabetes mellitus and periodontal diseases. Journal of Periodontology, 2006; 77(8):1289- 1303.
  • 29. Mealey BL, Ocampo GL: Diabetes mellitus and periodontal disease. Periodontology 2000, 2007; 44(1):127-153
  • 30. Miller AJ, Brunella JA, Carlos JP: National Institute of Dental Research. Oral Health of United States Adults: The National Survey of Oral Health in U.S. Employed Adults and seniors: 1985-86. National Findings. Bethesda, MD: National Institutes of Health, NIH Publication No. NIH-87-2868, 1987.
  • 31. Miller LS, Manwell MA, Newbold D, Reding ME, Rasheed A, Blodgett J, Kornman KS: The relationship between reduction in periodontal inflammation and diabetes control: a report of 9 cases. Journal of Periodontology, 1992; 63(10): 843-848.
  • 32. Nishimura F, Takahashi K, Kurihara M, Takashiba S, Murayama Y: Periodontal disease as a complication of diabetes mellitus. Annals of periodontology, 1998; 3(1): 20 – 29.
  • 33. Nishimura F, Murayama Y: Periodontol inflammation and insulin resistance- lessons from obesity. Journal of Dental Research, 2001; 80(8): 1690-1694.
  • 34. Noack B, Genco RJ, Trevisan M, Grossi S, Zambon JJ, De Nardin E: Periodontal infections contribute to elevated systemic C-reactive protein level. Journal of Periodontology, 2001;72(9):1221-1227.
  • 35. Papapanou PN: Periodontal disease epidemiology. Annals of Periodontalogy, 1996; 1(1):1-36.
  • 36. Ramamurthy NS, Golub LM: Diabetes increases collagenase activity in extracts of rat gingiva and skin. Journal of Periodontal Research, 1983; 18(1): 23-30.
  • 37. Ryan ME, Ramamurthy S, Golub LM: Matrix metalloproteinases and their inhibition in periodontal treatment. Current Opinion in Periodontics, 1996; 3: 85-96.
  • 38. Salvi GE, Collins JG, Yalda B, Arnold RR, Lang NP, Offenbacher S: Monocytic TNF alpha secretion patterns in IDDM patients with periodontal diseases. Journal of Clinical Periodontology, 1997; 24(1): 8-16.
  • 39. Sammalkorpi K: Glucose intolerance in acute infections. Journal of Internal Medicine, 1989; 225(1): 15-19.
  • 40. Schmidt AM, Hori O, Brett J, Yan SD, Wautier JL, Stern D: Cellular receptors for advanced glycation end products. Implications for induction of oxidant stress and cellular dysfunction in the pathogenesis of vascular lesions. Journal of Atherosclerosis and Thrombosis, 1994; 14(10):1521-1528.
  • 41. Schmidt AM, Hori O, Cao R, Yan SD, Brett J, Wautier JL, Ogawa S, Kuwabara K, Matsumoto M, Stern D: RAGE: a novel cellular receptor for advanced glycation end products. Diabetes, 1996; 45(Suppl 3): S77 – S80
  • 42. Seppälä B, Sorsa T, Ainamo J: Morphometric analysis of cellular and vascular changes in gingival connective tissue in long-term insulin-dependent diabetes. Journal of Periodontology, 1997; 68(12): 1237 – 1245.
  • 43. Stewart JE, Wager KA, Friedlander AH, Zadeh HH: The effect of periodontal treatment on glycemic control in patients with type 2 diabetes mellitus. Journal of Clinical Periodontology, 2001; 28(4): 306-310.
  • 44. Szopa TM, Titchener PA, Portwood ND, Taylor KW: Diabetes mellitus due to viruses-some recent developments. Diabetologia, 1993; 36(8):687-695.
  • 45. Tan WC, Tay FB, Lim LP: Diabetes as a risk factor for periodontal disease: current status and future considerations. Annals of the Academy of Medicine Singapore, 2006; 35(8): 571-581.
  • 46. Taylor GW, Burt BA, Becker MP, Genco RJ, Shlossman M, Knowler WC, Pettitt DJ: Severe periodontitis and risk for poor glycemic control in patients with non-insulindependent diabetes mellitus. Journal of Periodontology, 1996; 67(Suppl 10): 1085 – 1093.
  • 47. Vlassara H, Brownlee M, Manogue KR, Dinarello CA, Pasagian A: Cachectin/TNF and IL-1 induced by glucose-modified proteins: Role in normal tissue remodeling. Science, 1988; 240(4858):1546-1548.
  • 48. Vlassara H, Bucala R: Recent progress in advanced glycation and diabetic vascular disease: role of advanced glycation end product receptors. Diabetes, 1996; 45 (Suppl 3): S65 –S66
  • 49. Vlassara H: Recent progress on the biologic and clinical significance of advanced glycosylation end products. Journal of Laboratory and Clinical Medicine, 1994; 124(1): 19-30.
  • 50. Yki-Järvinen H, Sammalkorpi K, Koivisto VA, Nikkilä EA: Severity, duration, and mechanisms of insulin resistance during acute infections. Journal of Clinical Endocrinology and Metabolism, 1989; 69(2): 317-323.