Study of Association of Serum Lipids with Diabetic Retinopathy in Type 2 Diabetes Mellitus
Authors/Creators
- 1. Department of Physiology, Government Medical College, Surat
- 2. Department of Ophthalmology, Government Medical College, Surat
Description
The present study was conducted to find out the role of serum lipids in the development of diabetic retinopathy in type II Diabetes Mellitus. One hundred fifty subjects aged 30-70 years attending OPD at Old Civil hospital, Surat, participated in the study and were divided into three groups. Group I included 50 healthy non-diabetic subjects who served as control. Group II included 50 diabetic subjects with no signs of diabetic retinopathy and Group III included 50 diabetics with diabetic retinopathy. Funduscopy under homatropine was done in all the subjects. Serum triglycerides and total cholesterol were estimated by enzymatic methods and High Density Lipoprotein by precipitation method. Serum Low density lipoprotein was calculated using Friedewald’s formula. It was found that triglyceride levels were significantly raised (p<0.05) in subjects with diabetic retinopathy as compared to those without diabetic retinopathy showing a positive association of Triglycerides with the incidence of diabetic retinopathy. Whereas no such association was found between low density lipoprotein and total cholesterol levels with the prevalence of diabetic retinopathy.
Files
6 Alpana Mathur.pdf
Files
(41.6 kB)
| Name | Size | Download all |
|---|---|---|
|
md5:3f2b89a5a6b1a90eb6f34cb37e923f0c
|
41.6 kB | Preview Download |
Additional details
References
- 1. Benarous R, Sasongko MB, Qureshi S, Fenwick E, Dirani M, Wong TY, Lamoureux EL: Differential association of serum lipids with diabetic retinopathy and diabetic macular edema. Investigative Ophthalmology and Visual Science, 2011;52(10):7464-7469
- 2. Chew EY, Klein ML, Ferris FL (3rd), Remaley NA, Murphy RP, Chantry K, Hoogwerf BJ, Miller D: Association of elevated serum lipid levels with retinal hard exudate in diabetic retinopathy. Early treatment diabetic retinopathy study (ETDRS) Report 22. Archives of Ophthalmology, 1996;114(9):1079-1084
- 3. Dornan TL, Carter RD, Bron AJ, Turner RC, Mann JI: Low density Lipoprotein cholesterol: An association with severity of diabetic retinopathy. Diabetologia, 1982;22(3):167-170.
- 4. Hove MN, Kristensen JK, Lauritzen T, Bek T: The prevalence of retinopathy in an unselected population of type 2 diabetes patients from Arhus County, Denmark. Acta ophthalmologica Scandinavica 2004; 82(4):443- 448.
- 5. Joussen AM, Murata T, Tsujikawa A, Kirchhof B, Bursell SE, Adamis AP: Leucocyte-mediated endothelial cell injury and death in Diabetic retina. American Journal of Pathology, 2001;158(1):147-152.
- 6. Keech AC, Mitchell P, Summanen PA, O'Day J, Davis TM, Moffitt MS, Taskinen MR, Simes RJ, Tse D, Williamson E, Merrifield A, Laatikainen LT, d'Emden MC, Crimet DC, O'Connell RL, Colman PG: Effect of finofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): a randomised controlled trial. Lancet, 2007;370(9600):1687-1697.
- 7. Klein BE, Klein R ,Moss SE: Is serum cholesterol associated with progression of diabetic retinopathy or macular oedema in persons with younger-onset diabetes of long duration? American Journal of ophthalmology, 1999;128(5):652-654.
- 8. Kulshreshtha OP, Nayar SK, Sharma DP: Role of serum lipids in diabetic retinopathy. Indian Journal of Ophthalmology, 1979; 27(4);116-118.
- 9. Larsson LI, Alm A, Lithner F, Dahlen G, Bergstrom R: The association of hyperlipedemia with retinopathy in diabetic patients aged 15-50years in the county of Umea. Acta Ophthalmologica Scandinavica, 1999;77(5):585- 591.
- 10. Lyons TJ, Jenkins AJ, Zheng D, Lackland DT, McGee D, Garvey WT, Klein RL: Diabetic retinopathy and serum lipoprotein subclasses in the DCCT/EDIC cohort. Investigative Ophthalmology Visual Science, 2004;45(3):910-918
- 11. Mohan R, Mohan V, Susheela L, Ramachandrann A, Viswanathan M: Increased LDL cholesterol in NonInsulin-dependent diabetics with maculopathy. Acta Diabetologica Latina, 1984;21(1):85-89.
- 12. Ozer PA, Unlu N, Demir MN, Hazirolan DO, Acar MA, Duman S: Serum lipid profile in diabetic macular edema. Journal of Diabetes and its Complications, 2009;23(4): 244-248.
- 13. Rema M, Srivastava BK, Anitha B, Deepa R, Mohan V: Association of serum lipids with diabetic retinopathy in urban South Indians-the Chennai Urban Rural Epidemiology Study (CURES) Eye Study-2. Diabetic Medicine, 2006;23(9):1029-1036.
- 14. Sachdev N, Sahni A: Association of systemic risk factors with the severity of retinal hard exudates in a north Indian population with type 2 diabetes. Journal of Postgraduate Medicine, 2010;56(1):3-6
- 15. Sasongko MB, Wong TY, Nguyen TT, Kawasaki R, Jenkins A, Shaw J, Wang JJ: Serum Apolipoprotein AI and B are strong biomarkers of diabetic retinopathy than traditional lipids. Diabetes Care, 2011;34(2):474-479
- 16. Uçgun NI, Yildirim Z, Kiliç N, Gürsel E: The importance of serum lipids in exudative diabetic macular edema in type 2 diabetic patients. Annals of the New York Academy of Sciences, Biogerontology: Mechanism and interventions, 2007;1100:213-217.