Published August 31, 2021
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An overview on the role of plant-derived tannins for the treatment of lung cancer
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- 1. Department of Biotechnology, BIT-Campus, Anna University, Tiruchirappalli, Tamil Nadu, India
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Rajasekar, Nandhine, Sivanantham, Ayyanar, Ravikumar, Vilwanathan, Rajasekaran, Subbiah (2021): An overview on the role of plant-derived tannins for the treatment of lung cancer. Phytochemistry (112799) 188: 1-12, DOI: 10.1016/j.phytochem.2021.112799, URL: http://dx.doi.org/10.1016/j.phytochem.2021.112799
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- urn:lsid:plazi.org:pub:FF94421B84215237F706D82D913FA734
References
- Akhtar, S., Meeran, S.M., Katiyar, N., Katiyar, S.K., 2009. Grape seed proanthocyanidins inhibit the growth of human non-small cell lung cancer xenografts by targeting insulin-like growth factor binding protein-3, tumor cell proliferation, and angiogenic factors. Clin. Canc. Res. 15, 821-831. https://doi.org/10.1158/1078-0432.CCR-08- 1901.
- Aqil, F., Gupta, A., Munagala, R., Jeyabalan, J., Kausar, H., Sharma, R.J., Singh, I.P., Gupta, R.C., 2012. Antioxidant and antiproliferative activities of anthocyanin/ ellagitannin-enriched extracts from Syzygium cumini L. ( Jamun, the Indian blackberry). Nutr. Canc. 64, 428-438. https://doi.org/10.1080/ 01635581.2012.657766.
- Barnes, R.C., Krenek, K.A., Meibohm, B., Mertens-Talcott, S.U., Talcott, S.T., 2016. Urinary metabolites from mango (Mangifera indica L. cv. Keitt) galloyl derivatives and in vitro hydrolysis of gallotannins in physiological conditions. Mol. Nutr. Food Res. 60, 542-550. https://doi.org/10.1002/mnfr.201500706.
- Barszcz, M., Taciak, M., Tu´snio, A., Skomial, J., 2018. Effects of dietar y level of tannic acid and protein on internal organ weights and biochemical blood parameters of ra ts. PLoS One 13, e0190769. https://doi.org/10.1371/journal.pone.0190769.
- Bhardwaj, V., Mandal, A.K.A., 2019. Next-generation sequencing reveals the role of epigallocatechin-3-gallate in regulating putative novel and known microRNAs which target the MAPK pathway in non-small-cell lung cancer A549 cells. Molecules 24 (368). https://doi.org/10.3390/molecules24020368.
- Bittner, K., Kemme, T., Peters, K., Kersten, S., D¨anicke, S., Humpf, H.-U., 2014. Systemic absorption and metabolism of dietary procyanidin B4 in pigs. Mol. Nutr. Food Res. 58, 2261-2273. https://doi.org/10.1002/mnfr.201400435.
- Booth, B.W., Inskeep, B.D., Shah, H., Park, J.P., Hay, E.J., Burg, K.J.L., 2013. Tannic acid preferentially targets estrogen receptor-positive breast cancer. Int. J. Breast Cancer 2013, 369609. https://doi.org/10.1155/2013/369609.
- Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R.L., Torre, L.A., Jemal, A., 2018. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA. Cancer J. Clin 68, 394-424. https://doi.org/ 10.3322/caac.21492.
- Brenes, A., Viveros, A., Chamorro, S., Arija, I., 2016. Use of polyphenol-rich grape byproducts in monogastric nutrition. A review. Anim. Feed Sci. Technol. 211, 1-17. https://doi.org/10.1016/j.anifeedsci.2015.09.016.
- Castellani, S., Trapani, A., Spagnoletta, A., di Toma, L., Magrone, T., Di Gioia, S., Mandracchia, D., Trapani, G., Jirillo, E., Conese, M., 2018. Nanoparticle delivery of grape seed-derived proanthocyanidins to airway epithelial cells dampens oxidative stress and inflammation. J. Transl. Med. 16 (1), 140. https://doi.org/10.1186/ s12967-018-1509-4.
- Cerd´a, B., Cer´on, J.J., Tom´as-Barber´an, F.A., Espin, J.C., 2003. Repeated oral administration of high doses of the pomegranate ellagitannin punicalagin to rats for 37 Days is not toxic. J. Agric. Food Chem. 51, 3493-3501. https://doi.org/10.1021/ jf020842c.
- Chen, L., Lee, M.J., Li, H., Yang, C.S., 1997. Absorption, distribution, elimination of tea polyphenols in rats. Drug Metab. Dispos 25, 1045-1050.
- Cheng, T.-Y.D., Cramb, S.M., Baade, P.D., Youlden, D.R., Nwogu, C., Reid, M.E., 2016. The international epidemiology of lung cancer: latest trends, disparities, and tumor characteristics. J. Thorac. Oncol. 11, 1653-1671. https://doi.org/10.1016/j. jtho.2016.05.021.
- Chung, K.-T., Wei, C.-I., Johnson, M.G., 1998. Are tannins a double-edged sword in biology and health? Trends Food Sci. Technol. 9, 168-175. https://doi.org/10.1016/ S0924-2244(98)00028-4.
- Corn´elio Favarin, D., Martins Teixeira, M., Lemos de Andrade, E., de Freitas Alves, C., Lazo Chica, J.E., Art´erio Sorgi, C., Faccioli, L.H., Paula Rogerio, A., 2013. Anti-inflammatory effects of ellagic acid on acute lung injury induced by acid in mice. Mediat. Inflamm. 2013, 164202. https://doi.org/10.1155/2013/164202.
- Cromie, M.M., Gao, W., 2015. Epigallocatechin-3-Gallate enhances the therapeutic effects of leptomycin B on human lung cancer A549 cells. Oxid. Med. Cell. Longev 2015, 217304. https://doi.org/10.1155/2015/217304.
- Dela Cruz, C.S., Tanoue, L.T., Matthay, R.A., 2011. Lung cancer: epidemiology, etiology, and prevention. Clin. Chest Med 32, 605-644. https://doi.org/10.1016/j. ccm.2011.09.001.
- Deprez, S., Brezillon, C., Rabot, S., Philippe, C., Mila, I., Lapierre, C., Scalbert, A., 2000. Polymeric proanthocyanidins are catabolized by human colonic microflora into lowmolecular-weight phenolic acids. J. Nutr. 130, 2733-2738. https://doi.org/ 10.1093/jn/130.11.2733.
- Deprez, S., Mila, I., Huneau, J.-F., Tome, D., Scalbert, A., 2001. Transport of proanthocyanidin dimer, trimer, and polymer across monolayers of human intestinal epithelial caco-2 cells. Antioxid. Redox Signal 3, 957-967. https://doi.org/10.1089/ 152308601317203503.
- Deshpande, A., Sicinski, P., Hinds, P.W., 2005. Cyclins and cdks in development and cancer: a perspective. Oncogene 24, 2909-2915. https://doi.org/10.1038/sj. onc.1208618.
- Elmore, S., 2007. Apoptosis: a review of programmed cell death. Toxicol. Pathol. 35, 495-516. https://doi.org/10.1080/01926230701320337.
- Espin, J.C., Gonz´alez-Barrio, R., Cerd´a, B., Lopez-Bote ´, C., Rey, A.I., Tomas-Barber ´´an, F. A., 2007. Iberian pig as a model to clarify obscure points in the bioavailability and metabolism of ellagitannins in humans. J. Agric. Food Chem. 55, 10476-10485. https://doi.org/10.1021/jf0723864.
- Espin, J.C., Larrosa, M., Garcia-Conesa, M.T., Tom´as-Barberan ´, F., 2013. Biological significance of urolithins, the gut microbial ellagic acid-derived metabolites: the evidence so far. Evidence-based complement. Altern. Med 2013, 270418. https:// doi.org/10.1155/2013/270418.
- Ferruzzi, M.G., Lobo, J.K., Janle, E.M., Cooper, B., Simon, J.E., Wu, Q.-L., Welch, C., Ho, L., Weaver, C., Pasinetti, G.M., 2009. Bioavailability of gallic acid and catechins from grape seed polyphenol extract is improved by repeated dosing in rats: implications for treatment in alzheimer' s disease. J. Alzheimer' s Dementia 18, 113-124. https://doi.org/10.3233/JAD-2009-1135.
- Forester, S.C., Lambert, J.D., 2014. Synergistic inhibition of lung cancer cell lines by (-)-epigallocatechin-3-gallate in combination with clinically used nitrocatechol inhibitors of catechol-O-methyltransferase. Carcinogenesis 35, 365-372. https://doi. org/10.1093/carcin/bgt347.
- Fu, S., Yang, Y., Liu, D., Luo, Y., Ye, X., Liu, Y., Chen, X., Wang, S., Wu, H., Wang, Y., Hu, Q., You, P., 2017. Flavonoids and tannins from Smilax China L. Rhizome induce apoptosis via mitochondrial pathway and MDM2-p53 signaling in human lung adenocarcinoma cells. Am. J. Chin. Med. 45, 369-384. https://doi.org/10.1142/ S0192415X17500239.
- Garcia-Villalba, R., Selma, M.V., Espin, J.C., Tom´as-Barber´an, F.A., 2019. Identification of novel urolithin metabolites in human feces and urine after the intake of a pomegranate extract. J. Agric. Food Chem. 67, 11099-11107. https://doi.org/ 10.1021/acs.jafc.9b04435.
- Gavrilescu, L.C., Denkers, E.Y., 2003. Apoptosis and the balance of homeostatic and pathologic responses to Protozoan infection. Infect. Immun 71, 6109-6115. https:// doi.org/10.1128/IAI.71.11.6109-6115.2003.
- Go, J., Kim, J.-E., Koh, E.-K., Song, S.-H., Seung, J.-E., Park, C.-K., Lee, H.-A., Kim, H.-S., Lee, J.-H., An, B.-S., Yang, S.-Y., Lim, Y., Hwang, D.-Y., 2015. Hepatotoxicity and nephrotoxicity of gallotannin-enriched extract isolated from Galla Rhois in ICR mice. Lab. Anim. Res. 31, 101-110. https://doi.org/10.5625/lar.2015.31.3.101.
- Gonthier, M.-P., Donovan, J.L., Texier, O., Felgines, C., Remesy, C., Scalbert, A., 2003. Metabolism of dietary procyanidins in rats. Free Radic. Biol. Med. 35, 837-844. https://doi.org/10.1016/S0891-5849(03)00394-0.
- Hodgson, J.M., Morton, L.W., Puddey, I.B., Beilin, L.J., Croft, K.D., 2000. Gallic acid metabolites are markers of black tea intake in humans. J. Agric. Food Chem. 48, 2276-2280. https://doi.org/10.1021/jf000089s.
- Hong, J., Lambert, J.D., Lee, S.-H., Sinko, P.J., Yang, C.S., 2003. Involvement of multidrug resistance-associated proteins in regulating cellular levels of
- Hsu, H.-W., Chiu, M.-C., Shih, C.-J., Matsuura, K., Yang, C.-C.S., 2019. Apoptosis as a primary defense mechanism in response to viral infection in invasive fire ant Solenopsis invicta. Virology 531, 255-259. https://doi.org/10.1016/j. virol.2019.03.015.
- Hu, D., Wang, G., Yu, J., Zhang, L., Huang, Y., Wang, D., Zhou, H., 2019. Epigallocatechin-3-gallate modulates long non-coding RNA and mRNA expression profiles in lung cancer cells. Mol. Med. Rep. 19, 1509-1520. https://doi.org/ 10.3892/mmr.2019.9816.
- Huang, J., Chen, S., Shi, Y., Li, C.H., Wang, X.J., Li, F.J., Wang, C.H., Meng, Q.H., Zhong, J.N., Liu, M., Wang, Z.M., 2017. Epigallocatechin gallate from green tea exhibits potent anticancer effects in A-549 non-small lung cancer cells by inducing apoptosis, cell cycle arrest and inhibition of cell migration. J. B.U.ON, 22 (6), 1422-1427.
- Jimenez-Ramsey, L.M., Rogler, J.C., Housley, T.L., Butler, L.G., Elkin, R.G., 1994. Absorption and distribution of 14C-labeled condensed tannins and related sorghum phenolics in chickens. J. Agric. Food Chem. 42, 963-967. https://doi.org/10.1021/ jf00040a024.
- Jin, H., Chen, J.X., Wang, H., Lu, G., Liu, A., Li, G., Tu, S., Lin, Y., Yang, C.S., 2015. NNKinduced DNA methyltransferase 1 in lung tumorigenesis in A/J mice and inhibitory effects of ( )-Epigallocatechin-3-Gallate. Nutr. Cancer 67, 167-176. https://doi.org/ 10.1080/01635581.2015.976314.
- Kahle, K., Huemmer, W., Kempf, M., Scheppach, W., Erk, T., Richling, E., 2007. Polyphenols are intensively metabolized in the human gastrointestinal tract after apple juice consumption. J. Agric. Food Chem. 55, 10605-10614. https://doi.org/ 10.1021/jf071942r.
- Kim, Jiyoung, Kim, Jaekyoon, Shim, J., Lee, C.Y., Lee, K.W., Lee, H.J., 2014. Cocoa phytochemicals: recent advances in molecular mechanisms on health. Crit. Rev. Food Sci. Nutr. 54, 1458-1472. https://doi.org/10.1080/10408398.2011.641041.
- Kim, K.-C., Lee, C., 2014. Reversal of cisplatin resistance by epigallocatechin gallate is mediated by downregulation of Axl and Tyro 3 expression in human lung cancer cells. Korean J. Physiol. Pharmacol 18, 61-66. https://doi.org/10.4196/ kjpp.2014.18.1.61.
- Kin, R., Kato, S., Kaneto, N., Sakurai, H., Hayakawa, Y., Li, F., Tanaka, K., Saiki, I., Yokoyama, S., 2013. Procyanidin C1 from Cinnamomi Cortex inhibits TGF-β- induced epithelial-to-mesenchymal transition in the A549 lung cancer cell line. Int. J. Oncol. 43, 1901-1906. https://doi.org/10.3892/ijo.2013.2139.
- Ko, H., 2015. Geraniin inhibits TGF-β1-induced epithelial-mesenchymal transition and suppresses A549 lung cancer migration, invasion and anoikis resistance. Bioorg. Med. Chem. Lett 25, 3529-3534. https://doi.org/10.1016/j.bmcl.2015.06.093.
- Konishi, Y., Hitomi, Y., Yoshioka, E., 2004. Intestinal absorption of p -coumaric and gallic acids in rats after oral administration. J. Agric. Food Chem. 52, 2527-2532. https://doi.org/10.1021/jf035366k.
- Konishi, Y., Kobayashi, S., Shimizu, M., 2003. Transepithelial transport of p -coumaric acid and gallic acid in caco-2 cell monolayers. Biosci. Biotechnol. Biochem. 67, 2317-2324. https://doi.org/10.1271/bbb.67.2317.
- Kresty, L.A., Howell, A.B., Baird, M., 2011. Cranberry proanthocyanidins mediate growth arrest of lung cancer cells through modulation of gene expression and rapid induction of apoptosis. Molecules 16, 2375-2390. https://doi.org/10.3390/ molecules16032375.
- Kuo, P.-L., Hsu, Y.-L., Lin, T.-C., Chang, J.-K., Lin, C.-C., 2005a. Induction of cell cycle arrest and apoptosis in human non-small cell lung cancer A549 cells by casuarinin from the bark of Terminalia arjuna Linn. Anticancer. Drugs 16, 409-415. https:// doi.org/10.1097/00001813-200504000-00007.
- Kuo, P.L., Hsu, Y.L., Lin, T.C., Lin, C.C., 2005b. The antiproliferative activity of prodelphinidin B-2 3'-O-gallate from green tea leaf is through cell cycle arrest and Fas-mediated apoptotic pathway in A549 cells. Food Chem. Toxicol. 43, 315-323. https://doi.org/10.1016/j.fct.2004.11.002.
- Lambert, J.D., Hong, J., Kim, D.H., Mishin, V.M., Yang, C.S., 2004. Piperine enhances the bioavailability of the tea polyphenol (-)-epigallocatechin-3-gallate in mice. J. Nutr. 134, 1948-1952. https://doi.org/10.1093/jn/134.8.1948.
- Lambert, J.D., Lee, M.-J., Lu, H., Meng, X., Hong, J.J.J., Seril, D.N., Sturgill, M.G., Yang, C.S., 2003. Epigallocatechin-3-Gallate is absorbed but extensively glucuronidated following oral administration to mice. J. Nutr. 133, 4172-4177. https://doi.org/10.1093/jn/133.12.4172.
- Lamouille, S., Xu, J., Derynck, R., 2014. Molecular mechanisms of epithelialmesenchymal transition. Nat. Rev. Mol. Cell Biol. 15, 178-196. https://doi.org/ 10.1038/nrm3758.
- Li, C., Lee, M.-J., Sheng, S., Meng, X., Prabhu, S., Winnik, B., Huang, B., Chung, J.Y., Yan, S., Ho, C.-T., Yang, C.S., 2000. Structural identification of two metabolites of catechins and their kinetics in human urine and blood after tea ingestion. Chem. Res. Toxicol. 13, 177-184. https://doi.org/10.1021/tx9901837.
- Li, H.J., Shen, H.R., Shao, G.F., Shi, B.M., 2017. Tannins from pomegranate seeds ameliorate renal injury in streptozotocin-induced diabetic rat through the activation of microRNA-495 via regulating SMAD7. Int. J. Clin. Exp. Med. 10, 2532-2540.
- Li, J., Wang, S., Yin, J., Pan, L., 2013. Geraniin induces apoptotic cell death in human lung adenocarcinoma A549 cells in vitro and in vivo. Can. J. Physiol. Pharmacol. 91, 1016-1024. https://doi.org/10.1139/cjpp-2013-0140.
- Liang, J., Cao, L., Zhang, L., Chun Wan, X., 2014. Preparation, characterization, and in vitro antitumor activity of folate conjugated chitosan coated EGCG nanoparticles. Food Sci. Biotechnol. 23 (2), 569-575. https://doi.org/10.1007/s10068-014-0078- 4.
- Lluis, L., Mutnoz, M., Rosa Nogu´es, M., S´anchez-Martos, V., Romeu, M., Giralt, M., Valls, J., Sol`a, R., 2011. Toxicology evaluation of a procyanidin-rich extract from grape skins and seeds. Food Chem. Toxicol. 49, 1450-1454. https://doi.org/ 10.1016/j.fct.2011.03.042.
- Ma, F.-W., Deng, Q.-F., Zhou, X., Gong, X.-J., Zhao, Y., Chen, H.-G., Zhao, C., 2016. The tissue distribution and urinary excretion study of gallic acid and protocatechuic acid after oral administration of Polygonum capitatum extract in rats. Molecules 21 (399). https://doi.org/10.3390/molecules21040399.
- Maeda, H., Khatami, M., 2018. Analyses of repeated failures in cancer therapy for solid tumors: poor tumor-selective drug delivery, low therapeutic efficacy and unsustainable costs. Clin. Transl. Med. 7, 11. https://doi.org/10.1186/s40169-018- 0185-6.
- Maisetta, G., Batoni, G., Caboni, P., Esin, S., Rinaldi, A.C., Zucca, P., 2019. Tannin profile, antioxidant properties, and antimicrobial activity of extracts from two Mediterranean species of parasitic plant Cytinus. BMC Complement. Altern. Med 19 (82). https://doi.org/10.1186/s12906-019-2487-7.
- Mao, J.T., Lu, Q.-Y., Xue, B., Neis, P., Zamora, F.D., Lundmark, L., Qualls, C., Massie, L., 2019. A pilot study of a grape seed procyanidin extract for lung cancer chemoprevention. Canc. Prev. Res. 12, 557-566. https://doi.org/10.1158/1940- 6207.CAPR-19-0053.
- Mao, J.T., Smoake, J., Park, H.K., Lu, Q.Y., Xue, B., 2016a. Grape seed procyanidin extract mediates antineoplastic effects against lung cancer via modulations of prostacyclin and 15-hete eicosanoid pathways. Canc. Prev. Res. 9, 925-932. https:// doi.org/10.1158/1940-6207.CAPR-16-0122.
- Mao, J.T., Xue, B., Smoake, J., Lu, Q.-Y., Park, H., Henning, S.M., Burns, W., Bernabei, A., Elashoff, D., Serio, K.J., Massie, L., 2016b. MicroRNA-19a/b mediates grape seed procyanidin extract-induced anti-neoplastic effects against lung cancer. J. Nutr. Biochem. 34, 118-125. https://doi.org/10.1016/j.jnutbio.2016.05.003.
- Mao, X., Wu, L.-F., Zhao, H., Liang, W.-Y., Chen, W.-J., Han, S.-X., Qi, Q., Cui, Y.-P., Li, S., Yang, G.-H., Shao, Y.-Y., Zhu, D., Wang, R.-F., You, Y., Zhang, L.-Z., 2016. Transport of corilagin, gallic acid, and ellagic acid from fructus phyllanthi tannin fraction in caco-2 cell monolayers. Evidence-based complement. Altern. Med 2016, 9205379. https://doi.org/10.1155/2016/9205379.
- Marin, L., Migu´elez, E.M., Villar, C.J., Lomb´o, F., 2015. Bioavailability of dietary polyphenols and gut microbiota metabolism: antimicrobial properties. BioMed Res. Int. 2015 https://doi.org/10.1155/2015/905215, 905215.
- Maurya, D.K., Nandakumar, N., Devasagayam, T.P.A., 2010. Anticancer property of gallic acid in A549, a human lung adenocarcinoma cell line, and possible mechanisms. J. Clin. Biochem. Nutr. 48, 85-90. https://doi.org/10.3164/jcbn.11- 004FR.
- Meerts, I.A.T.M., Verspeek-Rip, C.M., Buskens, C.A.F., Keizer, H.G., Bassaganya-Riera, J., Jouni, Z.E., van Huygevoort, A.H.B.M., van Otterdijk, F.M., van de Waart, E.J., 2009. Toxicological evaluation of pomegranate seed oil. Food Chem. Toxicol. 47, 1085-1092. https://doi.org/10.1016/j.fct.2009.01.031.
- Miller, K.D., Nogueira, L., Mariotto, A.B., Rowland, J.H., Yabroff, K.R., Alfano, C.M., Jemal, A., Kramer, J.L., Siegel, R.L., 2019. Cancer treatment and survivorship statistics, 2019. CA. Cancer J. Clin 69, 363-385. https://doi.org/10.3322/ caac.21565.
- Molina, J.R., Yang, P., Cassivi, S.D., Schild, S.E., Adjei, A.A., 2008. Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship. Mayo Clin. Proc. 83, 584-594. https://doi.org/10.4065/83.5.584.
- Moorthy, M., Khoo, J.J., Palanisamy, U.D., 2019. Acute oral toxicity of the ellagitannin geraniin and a geraniin-enriched extract from Nephelium lappaceum L rind in Sprague Dawley rats. Heliyon 5, e02333. https://doi.org/10.1016/j.heliyon.2019. e02333.
- Niu, X., Zhao, H., Zhu, W., Zhao, Y., Cao, X., Xing, L., 2020. Efficacy of oral epigallocatechin-3-gallate solution administration during radiotherapy for non-small-cell lung cancer patients: a long-term observational study. Radiat. Med. Prot 1, 94-98. https://doi.org/10.1016/j.radmp.2020.05.001.
- Ohnuma, T., Anzai, E., Suzuki, Y., Shimoda, M., Saito, S., Nishiyama, T., Ogura, K., Hiratsuka, A., 2015. Selective antagonization of activated Nrf2 and inhibition of cancer cell proliferation by procyanidins from Cinnamomi Cortex extract. Arch. Biochem. Biophys. 585, 17-24. https://doi.org/10.1016/j.abb.2015.09.007.
- Ohnuma, T., Matsumoto, T., Itoi, A., Kawana, A., Nishiyama, T., Ogura, K., Hiratsuka, A., 2011. Enhanced sensitivity of A549 cells to the cytotoxic action of anticancer drugs via suppression of Nrf2 by procyanidins from Cinnamomi Cortex extract. Biochem. Biophys. Res. Commun. 413, 623-629. https://doi.org/10.1016/j.bbrc.2011.09.014.
- Ohnuma, T., Sakamoto, K., Shinoda, A., Takagi, C., Ohno, S., Nishiyama, T., Ogura, K., Hiratsuka, A., 2017. Procyanidins from Cinnamomi Cortex promote proteasomeindependent degradation of nuclear Nrf2 through phosphorylation of insulin-like growth factor-1 receptor in A549 cells. Arch. Biochem. Biophys. 635, 66-73. https:// doi.org/10.1016/j.abb.2017.10.007.
- Pandey, K.B., Rizvi, S.I., 2009. Plant polyphenols as dietary antioxidants in human health and disease. Oxid. Med. Cell. Longev 2, 270-278. https://doi.org/10.4161/ oxim.2.5.9498.
- Pattarayan, D., Sivanantham, A., Bethunaickan, R., Palanichamy, R., Rajasekaran, S., 2018a. Tannic acid modulates fibroblast proliferation and differentiation in response to pro-fibrotic stimuli. J. Cell. Biochem. 119, 6732-6742. https://doi.org/10.1002/ jcb.26866.
- Pattarayan, D., Sivanantham, A., Krishnaswami, V., Loganathan, L., Palanichamy, R., Natesan, S., Muthusamy, K., Rajasekaran, S., 2018b. Tannic acid attenuates TGF-β1- induced epithelial-to-mesenchymal transition by effectively intervening TGF-β signaling in lung epithelial cells. J. Cell. Physiol. 233, 2513-2525. https://doi.org/ 10.1002/jcp.26127.
- Pei, X., Xiao, J., Wei, G., Zhang, Y., Lin, F., Xiong, Z., Lu, L., Wang, X., Pang, G., Jiang, Y., Jiang, L., 2019. Oenothein B inhibits human non-small cell lung cancer A549 cell proliferation by ROS-mediated PI3K/Akt/NF-κB signaling pathway. Chem. Biol. Interact. 298, 112-120. https://doi.org/10.1016/j.cbi.2018.09.021.
- Pizzi, A., 2019. Tannins: prospectives and actual industrial applications. Biomolecules 9 (344). https://doi.org/10.3390/biom9080344.
- Punathil, T., Katiyar, S.K., 2009. Inhibition of non-small cell lung cancer cell migration by grape seed proanthocyanidins is mediated through the inhibition of nitric oxide, guanylate cyclase, and ERK1/2. Mol. Carcinog. 48, 232-242. https://doi.org/ 10.1002/mc.20473.
- Rajasekar, N., Sivanantham, A., Kar, A., Mahapatra, S.K., Ahirwar, R., Thimmulappa, R. K., Paramasivam, S.G., Subbiah, R., 2020. Tannic acid alleviates experimental pulmonary fibrosis in mice by inhibiting inflammatory response and fibrotic process. Inflammopharmacology 28, 1301-1314. https://doi.org/10.1007/s10787-020- 00707-5.
- Rajasekaran, S., Rajasekar, N., Sivanantham, A., 2021. Therapeutic potential of plant-derived tannins in non-malignant respiratory diseases. J. Nutr. Biochem. 94, 108632. https://doi.org/10.1016/j.jnutbio.2021.108632.
- Rios, L.Y., Bennett, R.N., Lazarus, S.A., R´em´esy, C., Scalbert, A., Williamson, G., 2002. Cocoa procyanidins are stable during gastric transit in humans. Am. J. Clin. Nutr. 76, 1106-1110. https://doi.org/10.1093/ajcn/76.5.1106.
- Roth, M., Timmermann, B.N., Hagenbuch, B., 2011. Interactions of green tea catechins with organic anion-transporting polypeptides. Drug metab. Dispos 39, 920-926. https://doi.org/10.1124/dmd.110.036640.
- Sang, S., Lambert, J.D., Ho, C.T., Yang, C.S., 2011. The chemistry and biotransformation of tea constituents. Pharmacol. Res. 64, 87-99. https://doi.org/10.1016/j. phrs.2011.02.007.
- Saura-Calixto, F., Serrano, J., Goni t, I., 2007. Intake and bioaccessibility of total polyphenols in a whole diet. Food Chem. 101, 492-501. https://doi.org/10.1016/j. foodchem.2006.02.006.
- Seeram, N.P., Henning, S.M., Zhang, Y., Suchard, M., Li, Z., Heber, D., 2006. Pomegranate juice ellagitannin metabolites are present in human plasma and some persist in urine for up to 48 hours. J. Nutr. 136, 2481-2485. https://doi.org/ 10.1093/jn/136.10.2481.
- Serrano, J., Puupponen-Pimi¨a, R., Dauer, A., Aura, A.-M., Saura-Calixto, F., 2009. Tannins: current knowledge of food sources, intake, bioavailability and biological effects. Mol. Nutr. Food Res. 53, S310-S329. https://doi.org/10.1002/ mnfr.200900039.
- Shahrzad, S., Aoyagi, K., Winter, A., Koyama, A., Bitsch, I., 2001. Pharmacokinetics of gallic acid and its relative bioavailability from tea in healthy humans. J. Nutr. 131, 1207-1210. https://doi.org/10.1093/jn/131.4.1207.
- Shao, Z.-H., Hoek, T.L., Vanden, Xie J., Wojcik, K., Chan, K.C., Li, C.-Q., Hamann, K., Qin, Y., Schumacker, P.T., Becker, L.B., Yuan, C.-S., 2003. Grape seed proanthocyanidins induce pro-oxidant toxicity in cardiomyocytes. Cardiovasc. Toxicol 3, 331-340. https://doi.org/10.1385/CT:3:4:331.
- Sharma, S.D., Meeran, S.M., Katiyar, S.K., 2010. Proanthocyanidins inhibit in vitro and in vivo growth of human non-small cell lung cancer cells by inhibiting the prostaglandin E2 and prostaglandin E2 receptors. Mol. Canc. Therapeut. 9, 569-580. https://doi.org/10.1158/1535-7163.MCT-09-0638.
- Siegel, R.L., Miller, K.D., Jemal, A., 2018. Cancer statistics, 2018. CA A Cancer J. Clin. 68, 7-30. https://doi.org/10.3322/caac.21442.
- Sieniawska, E., Baj, T., 2017. Tannins. In: Pharmacognosy. Elsevier, pp. 199-232. https://doi.org/10.1016/B978-0-12-802104-0.00010-X.
- Singh, T., Sharma, S.D., Katiyar, S.K., 2011. Grape proanthocyanidins induce apoptosis by loss of mitochondrial membrane potential of human non-small cell lung cancer cells in vitro and in. Vivo. PLoS One 6, e27444. https://doi.org/10.1371/journal. pone.0027444.
- Sivanantham, A., Pattarayan, D., Bethunaickan, R., Kar, A., Mahapatra, S.K., Thimmulappa, R.K., Palanichamy, R., Rajasekaran, S., 2019a. Tannic acid protects against experimental acute lung injury through downregulation of TLR4 and MAPK. J. Cell. Physiol. 234, 6463-6476. https://doi.org/10.1002/jcp.27383.
- Rajasekaran, S., 2019b. Tannic acid prevents macrophage-induced pro-fibrotic response in lung epithelial cells via suppressing TLR4-mediated macrophage polarization. Inflamm. Res. 68, 1011-1024. https://doi.org/10.1007/s00011-019- 01282-4.
- Smart, R.C., Huang, M.T., Chang, R.L., Sayer, J.M., Jerina, D.M., Conney, A.H., 1986. Disposition of the naturally occurring antimutagenic plant phenol, ellagic acid, and its synthetic derivatives, 3-o-decylellagic acid and 3, 3'-di-o-methylellagic acid in mice. Carcinogenesis 7, 1663-1667. https://doi.org/10.1093/carcin/7.10.1663.
- Solano-G´alvez, S., Abadi-Chiriti, J., Guti´errez-Velez, L., Rodriguez-Puente, E., Konstat- Korzenny, E., Alvarez-Hern ´´andez, D.-A., Franyuti-Kelly, G., Guti´errez-Kobeh, L., V´azquez-L´opez, R., 2018. Apoptosis: activation and inhibition in health and disease. Med. Sci. 6 (54) https://doi.org/10.3390/medsci6030054.
- Sonoda, J.I., Ikeda, R., Baba, Y., Narumi, K., Kawachi, A., Tomishige, E., Nishihara, K., Takeda, Y., Yamada, K., Sato, K., Motoya, T., 2014. Green tea catechin, epigallocatechin-3-gallate, attenuates the cell viability of human non-small-cell lung cancer A549 cells via reducing Bcl-xL expression. Exp. Ther. Med 8, 59-63. https:// doi.org/10.3892/etm.2014.1719.
- Sp, N., Kang, D.Y., Kim, D.H., Yoo, J.-S., Jo, E.S., Rugamba, A., Jang, K.-J., Yang, Y.M., 2020. Tannic acid inhibits non-small cell lung cancer (NSCLC) stemness by inducing G 0/G 1 cell cycle arrest and intrinsic apoptosis. Anticancer Res. 40, 3209-3220. https://doi.org/10.21873/anticanres.14302.
- Subkamkaew, C., Limtrakul(Dejkriengkraikul), P., Yodkeeree, S., 2019. Proanthocyanidin-rich fractions from red rice extract enhance TNF-α- induced cell death and suppress invasion of human lung adenocarcinoma cell A549. Molecules 24, 3393. https://doi.org/10.3390/molecules24183393.
- Toda, K., Ueyama, M., Tanaka, S., Tsukayama, I., Mega, T., Konoike, Y., Tamenobu, A., Bastian, F., Akai, I., Ito, H., Kawakami, Y., Takahashi, Y., Suzuki-Yamamoto, T., 2020. Ellagitannins from Punica granatum leaves suppress microsomal prostaglandin E synthase-1 expression and induce lung cancer cells to undergo apoptosis. Biosci. Biotechnol. Biochem. 84, 757-763. https://doi.org/10.1080/ 09168451.2019.1706442.
- Vaid, M., Katiyar, S.K., 2015. Grape seed proanthocyanidins inhibit cigarette smoke condensate-induced lung cancer cell migration through inhibition of NADPH oxidase and reduction in the binding of p22 phox and p47 phox proteins. Mol. Carcinogenesis (Oxf.) 54, E61-E71. https://doi.org/10.1002/mc.22173.
- Wang, J., Sun, P., Wang, Q., Zhang, P., Wang, Y., Zi, C., Wang, X., Sheng, J., 2019.
- Wang, R., Ma, L., Weng, D., Yao, J., Liu, X., Jin, F., 2016. Gallic acid induces apoptosis and enhances the anticancer effects of cisplatin in human small cell lung cancer H446 cell line via the ROS-dependent mitochondrial apoptotic pathway. Oncol. Rep. 35, 3075-3083. https://doi.org/10.3892/or.2016.4690.
- Warden, B.A., Smith, L.S., Beecher, G.R., Balentine, D.A., Clevidence, B.A., 2001. Catechins are bioavailable in men and women drinking black tea throughout the day. J. Nutr. 131, 1731-1737. https://doi.org/10.1093/jn/131.6.1731.
- Wendt, M.K., Allington, T.M., Schiemann, W.P., 2009. Mechanisms of the epithelial-mesenchymal transition by TGF-β. Futur. Oncol. 5, 1145-1168. https:// doi.org/10.2217/fon.09.90.
- Whitley, A.C., Stoner, G.D., Darby, M.V., Walle, T., 2003. Intestinal epithelial cell accumulation of the cancer preventive polyphenol ellagic acid-extensive binding to protein and DNA. Biochem. Pharmacol. 66, 907-915. https://doi.org/10.1016/ S0006-2952(03)00413-1.
- Wu, L., Huang, Z., Qin, P., Yao, Y., Meng, X., Zou, J., Zhu, K., Ren, G., 2011. Chemical characterization of a procyanidin-rich extract from sorghum bran and its effect on oxidative stress and tumor inhibition in vivo. J. Agric. Food Chem. 59, 8609-8615. https://doi.org/10.1021/jf2015528.
- Xue, B., Lu, Q.Y., Massie, L., Qualls, C., Mao, J.T., 2018. Grape seed procyanidin extract against lung cancer: the role of microrna-106b, bioavailability, and bioactivity. Oncotarget 9. https://doi.org/10.18632/oncotarget.24528, 15579.
- Yamagishi, M., Natsume, M., Osakabe, N., Okazaki, K., Furukawa, F., Imazawa, T., Nishikawa, A., Hirose, M., 2003. Chemoprevention of lung carcinogenesis by cacao liquor proanthocyanidins in a male rat multi-organ carcinogenesis model. Canc. Lett. 191, 49-57. https://doi.org/10.1016/S0304-3835(02)00629-8.
- Yamakoshi, J., Saito, M., Kataoka, S., Kikuchi, M., 2002. Safety evaluation of proanthocyanidin-rich extract from grape seeds. Food Chem. Toxicol. 40, 599-607. https://doi.org/10.1016/S0278-6915(02)00006-6.
- Yang, C.S., Sang, S., Lambert, J.D., Lee, M.J., 2008. Bioavailability issues in studying the health effects of plant polyphenolic compounds. Mol. Nutr. Food Res. 52, S139-S151. https://doi.org/10.1002/mnfr.200700234.
- Yang, L., Shi, P., Zhao, G., Xu, J., Peng, W., Zhang, J., Zhang, G., Wang, X., Dong, Z., Chen, F., Cui, H., 2020. Targeting cancer stem cell pathways for cancer therapy. Signal Transduct. Target. Ther 5, 8. https://doi.org/10.1038/s41392-020-0110-5.
- Younes, M., Aggett, P., Aguilar, F., Crebelli, R., Dusemund, B., Filipic ˇ, M., Frutos, M.J., Galtier, P., Gott, D., Gundert-Remy, U., Lambr´e, C., Leblanc, J., Lillegaard, I.T., Moldeus, P., Mortensen, A., Oskarsson, A., Stankovic, I., Waalkens-Berendsen, I., Woutersen, R.A., Andrade, R.J., Fortes, C., Mosesso, P., Restani, P., Arcella, D., Pizzo, F., Smeraldi, C., Wright, M., 2018. Scientific opinion on the safety of green tea catechins. EFSA J 16, e05239. https://doi.org/10.2903/j.efsa.2018.5239.
- Yu, C., Jiao, Y., Xue, J., Zhang, Q., Yang, H., Xing, L., Chen, G., Wu, J., Zhang, S., Zhu, W., Cao, J., 2017. Metformin sensitizes non-small cell lung cancer cells to an epigallocatechin-3-gallate (EGCG) treatment by suppressing the Nrf2/HO-1 signaling pathway. Int. J. Biol. Sci. 13, 1560-1569. https://doi.org/10.7150/ ijbs.18830.
- Yu, S.-M., Gweon, E.-J., Chung, K.-W., Kim, K.-H., Cho, H.-S., Kim, S.-J., 2012. Gallotannin regulates apoptosis and COX-2 expression via Akt and p38kinase pathway in human lung cancer cell line, A549. Animal Cells Syst. (Seoul) 16, 366-375. https://doi.org/10.1080/19768354.2012.696553.
- Zhang, L., Wang, Y., Li, D., Ho, C.T., Li, J., Wan, X., 2016. The absorption, distribution, metabolism and excretion of procyanidins. Food Funct 7, 1273-1281. https://doi. org/10.1039/c5fo01244a.
- Zhao, H., Liu, T., Mao, X., Han, S., Liang, R., Hui, L., Cao, C., You, Y., Zhang, L., 2015. Fructus phyllanthi tannin fraction induces apoptosis and inhibits migration and invasion of human lung squamous carcinoma cells in vitro via MAPK/MMP pathways. Acta Pharmacol. Sin 36, 758-768. https://doi.org/10.1038/ aps.2014.130.
- Zhao, H., Zhu, W., Xie, P., Li, H., Zhang, X., Sun, X., Yu, J., Xing, L., 2014. A phase I study of concurrent chemotherapy and thoracic radiotherapy with oral epigallocatechin-3- gallate protection in patients with locally advanced stage III non-small-cell lung cancer. Radiother. Oncol. 110, 132-136. https://doi.org/10.1016/j. radonc.2013.10.014.
- Zhou, D.-H., Wang, X., Yang, M., Shi, X., Huang, W., Feng, Q., 2013. Combination of low concentration of ( )-Epigallocatechin gallate (EGCG) and curcumin strongly suppresses the growth of non-small cell lung cancer in vitro and in vivo through causing cell cycle arrest. Int. J. Mol. Sci. 14, 12023-12036. https://doi.org/ 10.3390/ijms140612023.