Clinical Profile of Patients with Multi-Organ Dysfunction Syndrome in Patients of Sepsis in Rural set up MICU
Authors/Creators
- 1. Department of Medicine, GMERS Medical College, Valsad
- 2. Department of Medicine, SBKS Medical Institute & RC, Pipariya, Vadodara(Gujarat)
Description
This study was conducted to assess morbidity and mortality in patients with sepsis, severe sepsis and multi-
organ dysfunction syndrome (MODS) with respect to different organs. Fifty patients having evidence of sepsis on day of
admission were studied. Detailed history, clinical assessment and routine laboratory investigations including blood culture
was done. The patients were defined with severe sepsis and MODS as per ACCP/SCCM guidelines of 1992. Tropical
sepsis (malaria and puerperal) was an important problem in our rural based MICU. Multi-organ dysfunction syndrome was
the leading cause of mortality (48%). The difference in mortality rate between severe sepsis (10%) group and MODS
(56.4%) group was statistically significant. In our study, lung (80%) was the most common organ affected followed by
kidneys (78%) on day of admission. Metabolic failure was least common, occurring in only 23% patients on day of
admission. But hematologic failure was persistent and most common organ failure after 3 days of admission. Patients with
lung and metabolic acidosis on the day of admission had unfavourable outcome. However, persistence of any organ
dysfunction beyond 3 days carried worse prognosis except hematological involvement. The difference of mortality between
MODS and severe sepsis group was statistically significant. Thus, early diagnosis is necessary before MODS sets in
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Additional details
References
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