People's Journal of Scientific Research
Published December 1, 2015 | Version v1
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Study of Serum Adiponectin, Insulin and Insulin Resistance in Offsprings of Diabetic Parents

Authors/Creators

  • 1. Department of Biochemistry, People's College of Medical Sciences & Research Centre, Bhopal

Description

Adiponectin is an adipocytokine that is exclusively expressed and secreted from adipose tissue. Its role as a protective adipokine is suggested by low levels in states of insulin resistance (IR), cardiovascular disease (CVD) and type 2 diabetes (T2DM). In present study we compared serum adiponectin, insulin and (IR) in offspring's of diabetic and nondiabetic parents and showed if any significant difference is there between both the groups. Analytical cross-sectional study was carried out. Subjects were randomly selected based on inclusion and exclusion criteria aged between 18-30 years and grouped in three groups: Group 1: 60 off-spring of non diabetic parents; Group 2: 38 off-spring of single diabetic parents; Group 3: 22 off-spring of both diabetic parents. In all the groups fasting plasma glucose, serum insulin and serum adiponectin were estimated. Statistical analysis was carried out to compare values with group3. Mean values of serum adiponectin were Group 1(10.25µg/ml ±1.68) group 2 (9.25 µg/ml ±1.81) and group 3 (10.86 µg/ml ± 1.23), Fasting blood sugar mean value in group1 :( 86.84mg/dl ± 6.25), group 2: (94.95 mg/dl ±6.58), group3: (85.23 mg/dl ±5.93), Insulin mean values in group1 (10.81 U/mL ±1.73), group2: (12.69 U/mL ±1.55), group 3 (8.69 U/mL ±2.55), Insulin resistance group1 (2.4±0.48), group2 (2.55±0.55), group3: (1.8±0.55). The values of all the three parameters were significantly different between three groups (p< 0.01). Serum level of adiponectin, insulin and insulin resistance were significantly different in offspring's of diabetic parents. Serum Adiponectin might play a key role in developing diabetes in near future.

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