Evaluation of Liver Function Test and Renal Function Test in Pre-eclampsia: A Case Control Study
Authors/Creators
- 1. Department of Biochemistry, Shri Shankracharya Institute of Medical Sciences, Bhilai, Chhattisgarh, India
Description
Pre-eclampsia is a multisystem disorder, which occurs only in pregnant women during the second and third
trimesters of pregnancy and is associated with raised blood pressure and proteinuria. Liver function Test (LFT)
abnormalities occur in 3% of the pregnancies and probably the lesion that causes elevated serum liver enzymes. With
severe renal involvement, glomerular filtration may be impaired and the plasma creatinine concentration begins to rise.
This study was conducted to compare the liver function tests and renal function tests in pre eclampsia with normal
pregnancy. This study was carried out on 60 pregnant women after 20 weeks of gestation admitted in Obstetrics &
Gynaecology units of Shri Shankaracharya Institute of Medical Sciences, Bhilai, Chhattisgarh. The subjects were
divided into two groups. Group A comprised of 30 cases of pre-eclampsia having blood pressure ≥ 140/90mm Hg,
proteinuria in 24 hours ≥ 300 mg and edema. Group B had 30 normal pregnant women after 20 weeks of gestation. The
data including parity, period of gestation, blood pressure and presenting complaints of all subjects were recorded. The
mean value of serum bilirubin in cases was 3.45 and in controls it was 0.50. The mean value of enzymes ALT in cases was
92.7 while in the controls it was 22.37. Mean serum AST in the cases was 85.43 and in the controls it was 21.96. Total
protein in cases was 7.77 and controls it was 7.26. Albumin level in cases was 4.62 and controls were 4.17. The mean
value of urea in cases was 43.76 and control it was 24.5. The mean value of Creatnine in cases was 1.51 and in control it
was 0.80. The mean value of Uric Acid in cases was 5.41 and in control it was 4.45. Increased concentrations of serum
bilirubin, total protein, albumin and liver enzymes ALT, AST,urea, creatinine and uric acid were found in pre-eclampsia
cases.
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References
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