People's Journal of Scientific Research
Published December 1, 2016 | Version v1
Journal article Open

Study of Biochemical Parameters in Rheumatoid Arthritis and Systemic Lupus Erythematosus

Authors/Creators

  • 1. Department of Biochemistry, Seth G.S. Medical College & K.E.M. Hospital, Parel, Mumbai
  • 2. Department of Pathology, Seth G.S. Medical College & K.E.M. Hospital, Parel, Mumbai
  • 3. Department of Anatomy, Seth G.S. Medical College & K.E.M. Hospital, Parel, Mumbai

Description

Dynamic tissue that is remodeled constantly throughout life. The arrangement of compact and cancellous bone provides a strength and density suitable for mobility. In addition, bone provides a reservoir for calcium, phosphorus, magnesium and other ions necessary for homeostatic functions. Dead bone must be resorbed, and new bone must be formed. The purpose of this study was to evaluate the parameters like calcium, phosphorus, magnesium, alkaline phosphatase and its isoenzymes in RA and systemic SLE. A study was conducted in rheumatoid arthritis, pre and post-menopausal women with RA and systemic lupus erythematosus patients and controls. The serum calcium was decreased, while phosphorus and alkaline phosphatase were increased in rheumatoid arthritis and systemic lupus erythematosus patients as compared to control subjects. The isoenzymes of alkaline phosphatase showed one diffuse band which was originated from bone. Low serum calcium and high phosphorus and alkaline phosphatase (ALP) indicate that SLE & RA patients had sick bone. The serum ALP isoenzyme (bone) is a biochemical marker for the assessment of bone mineralization and monitoring the therapy with bisphosphonates which are bone strengthing agents

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