Which is more effective for Nebulization in Bronchiolitis: Hypertonic Saline or Epinephrine
Authors/Creators
- 1. Department of Paediatrics, Maharani Laxmi Bai Medical College, Jhansi (Uttar Pradesh)
Description
A prospective, open labelled, controlled trial was conducted in tertiary care centre, using standard therapy ie epinephrine and hypertonic saline as study drug in two group of patients. Children 2 month to 24 months of age with first episode of bronchiolitis were included in the study while excluding those with cardiac disease, immuno deficiency and critical illness at presentation. Nebulized epinephrine in Group A (epinephrine group) (n=33) and hypertonic saline group B (n=32) was used in patients of bronchiolitis ,respiratory score at admission and after 24 hrs and duration of stay of both the groups were compare.In adrenaline group and hypertonic saline group, there was no statistical significant difference in base line admission clinical score whereas hypertonic saline was more effective for clinical score at 24 hours(p<0.05) and duration of stay(p<0.05) Nebulised hypertonic saline was found to be safe, effective and superior to adrenaline (standard therapy) in management of bronchiolitis in this study
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Additional details
References
- 1. Guideline Diagnosis and management of bronchiolitis. Pediat 2006;118(4):1774-93.
- 2. Destino L, Welsgerber MC. Validity of Respiratory Score in Bronchiolitis. Annual meeting of the PaediatricsAcademic Society, 2010; 2154-1671.
- 3. Parrott RH, Kim HW,Arrobio JO, Hodes DS, Murphy BR, Brandt CD, Camargo E, Chanock RM. Epidemiology of respiratory syncytial virus infection in Washington, D.C.II. Infection and disease with respect to age, immunologic ststus, race and sex.Am J Epidemiol. 1973;98(4):289-300
- 4. Kravitz H. Sex distribution of hospitalized children with acute respiratory diseases, gastroenteritis and meningitis, Clin Paediatr ; 1965: 411-455.
- 5. Gardner PS, McQuillin J, Court SD. Speculation on pathogenesis in death from respiratory syncytial virus infection. Br Med J.1970;1(5692):327-330.
- 6. Spence l, Barrat N. Resiratory syncytial virus associated with acute respiratory Infections in Trinidadian patients. J Epidemiol1968;88:257- Am 66
- 7. Kim HW, Arrobio JO, Brandt CD , Jeffries BC, Pyles G, Reid JL, Chanock RM, Parrott RH. Epidemiology of respiratory syncytial virus infection in Washington, D.C.I. Importance of the virus in different respiratory tract disease syndromes and temporal distribution of infection .Am J Epidemiol. 1973;98(3):216-225.
- 8. Gupta N, Pulliyel A, Man Chanda A, Pulliyel J. Nebulized hypertonic sanie vs epinephrine for bronchiolitis :Prof of concept study of cumulative sum analysis: Indian Paeditr 2012; 49(7):543-7.
- 9. Sharma BS, Gupta MK, Rafik SP. Hypertonic (3%) saline vs 0.93% saline nebulization for acute viral bronchiolitis: a randomized controlled trial. Indian Pediatr. 2013;50(8):743-747.
- 10. Khalid Ansari, Mahmoud Sakran, Bruce L Davidson MD, HellaMahjoub. Nebulized 5% or 3% hypertonic or 0.9% saline for treating acute bronchiolitis in infants. J Paediatr Child Health. 2010; 157:630-634.
- 11. Jaffery Baron. Hypeton Hypertonic Saline for the Treatment of Bronchiolitis in Infants and Young Children: A Critical Review of the Literature. 21(1):7- 26.