Vitamin D Levels and Severity of Cirrohosis: A Cross Sectional Study
Authors/Creators
- 1. Department of Medicine, People's College of Medical Sciences & Research Centre, Bhopal
Description
Low 25(OH) vitamin D concentration is observed to be associated with liver dysfunction and predict hepatic
decompensation and mortality in patients with chronic liver disease. The objectives of the study were to estimate serum
vitamin D levels in patients with chronic liver disease; to find out the severity of cirrhosis according to Child Pugh
Classification and to find out the relationship between severity of cirrhosis (Child Pugh) with levels of serum Vitamin D.
This cross sectional study was conducted amongst 100 patients presenting with cirrhosis of liver to OPD or admitted in a
tertiary care hospital during study period year 2017-2018. Details regarding socio-demographic variables and history were
obtained followed by physical and biochemical examination. Data was compiled using MS excel and analysed using Epi
Info 7.2 software. Majority of the patients were in the age group 41-60 years with male preponderance. Mean Vitamin D
level estimated in the study being 13.9±7.7 was highest in the Child Pugh Class A and lowest in the Child Pugh Class C. The
association of mean Vitamin D in relation to Child Pugh Class was found to be statistically significant (p<0.05). The present
study found low levels of Vitamin D in patients with cirrhosis. The severity of cirrhosis as assessed by Child Pugh Score was
inversely proportional to the Vitamin D level.
Files
5.pdf
Files
(64.7 kB)
| Name | Size | Download all |
|---|---|---|
|
md5:04ead4709f40e6f6c9b0a04f96e21f65
|
64.7 kB | Preview Download |
Additional details
References
- 1. Khazai N, Judd SE, Tangpricha V. Calcium and vitamin D: skeletal and extraskeletal health. Curr Rheumatol Rep. 2008;10(2):110-7.
- 2. Jones G, Prosser DE, Kaufmann M. Cytochrome P450- mediated metabolism of vitamin D. J Lipid Res. 2014;55(1):13-31.
- 3. Cashman KD, van den Heuvel EG, Schoemaker RJ, Prévéraud DP, Macdonald HM, Arcot J. 25- Hydroxyvitamin D as a biomarker of vitamin D status and its modeling to inform strategies for prevention of vitamin D deficiency within the population. Adv Nutr. 2017;8(6):947-957.
- 4. Anty R, Tonohouan M, Ferrari-Panaia P, Piche T, ParienteA,Anstee QM, Gual P, TranA. Low levels of 25-hydroxy vitamin d are independently associated with the risk of bacterial infection in cirrhotic patients. Clin Transl Gastroenterol. 2014;29(5):e56.
- 5. Nair S. Vitamin d deficiency and liver disease. Gastroenterol Hepatol. 2010;6(8):491.
- 6. Paternostro R, Wagner D, Reiberger T, Mandorfer M, Schwarzer R, Ferlitsch M, Trauner M, Peck- Radosavljevic M, Ferlitsch A. Low 25-OH-vitamin D levels reflect hepatic dysfunction and are associated with mortality in patients with liver cirrhosis. Wien Klin Wochenschr. 2017;129(1-2):8- 15.
- 7. Iruzubieta P, Terán Á, Crespo J, Fábrega E. Vitamin D deficiency in chronic liver disease. World J Hepatol. 2014;6(12):901.
- 8. Barchetta I. Could vitamin d supplementation benefit patients with chronic liver disease?. Gastroenterol Hepatol. 2012;8(11):755.
- 9. Rech MA, Von Roenn N, Durazo-Arvizu R, Cotler SJ, Kramer H. Vitamin D Levels are Associated with Liver Disease Severity in Patients with Cirrhosis. J Ren Hep Disord. 2017;1(2):1-9.
- 10. Balde J, Rao NK, Ballala K, Samanth J, Shetty KR, Patil N, Avinash A, Varghese G. Echocardiographic abnormalities in cirrhosis & their correlation with severity of cirrhosis using Child-Pugh score among patients in a tertiary care hospital. Ind J Med Res. 2016;144(6):935.
- 11. Monika Dezortova, et al. Etiology and functional status of liver cirrhosis by 31P MR spectroscopy. World J Gastroenterolo.2005;11(44): 6924- 8931.
- 12. Haq MI, Salim A, Malik K, Dilshad A, Amin J, Butt AK, Alam A. Correlation of Child-Pugh Class of Cirrhosis and Lipid Profile. Proceeding SZPGMI. 2016;30(1):19-23.
- 13. Jamil Z, Arif S, Khan A, Durrani AA, Yaqoob N. Vitamin D Deficiency and Its Relationship with Child-Pugh Class in Patients with Chronic Liver Disease. J Clin Transla Hepatol. 2018;1;6(2):1-6.
- 14. Fernández Fernández N, Linares Torres P, Joáo Matias D, Jorquera Plaza F, OlcozGoñi JL. Vitamin D deficiency in chronic liver disease, clinical- epidemiological analysis and report after vitamin d supplementation. Gastroenterol Hepatol. 2016;39 :305–310.
- 15. Zhao XY, Li J, Wang JH, Habib S, Wei W, Sun SJ, et al. Vitamin D serum level is associated with Child- Pugh score and metabolic enzyme imbalances, but not viral load in chronic hepatitis B patients. Medicine (Baltimore) 2016;95: e3926.