PRIMPOL ensures robust handoff between on-the-fly and post-replicative DNA lesion bypass.

Supplementary Table 6. CRISPR screen raw sgRNA counts.

Excel sheet ‘Mellor et al Table S6_sgRNA_count.xlsx’.

Output of the MAGeCK count command aligning Illumina sequencing reads to the sgRNA sequences within the Human Improved Genome-wide Knockout CRISPR library, following CRISPR/Cas9 screens in WT and primpol TK6 cells.

Supplementary Table 7. CRISPR screen untreated summary.

Excel sheet ‘Mellor et al Table S7_untreated_summary.xlsx’.

Output of the MAGeCK test command comparing sgRNA abundance between the sequencing libraries produced following a CRISPR/Cas9 knockout screen in WT versus primpol TK6 cells in untreated conditions.

Supplementary Table 8. CRISPR screen cisplatin treated summary.

Excel sheet ‘Mellor et al Table S8_cddp_treated_summary.xlsx’.

Output of the MAGeCK test command comparing sgRNA abundance between the sequencing libraries produced following a CRISPR/Cas9 knockout screen in WT versus primpol TK6 cells challenged with 7 days continuous 0.25 μM cisplatin treatment.

readme.xlsx

Tab 1: List of files

Tab 2: Summary of CRISPR screen samples & conditions