Background and aims – The paleotropical genus Neuropeltis of the Convolvulaceae is imperfectly known. The present paper aims to revise the genus for the Upper Guinea area in West Africa. Methods – Normal practices of herbarium taxonomy have been applied to study all herbarium material available. Key results – Three species are found in Upper Guinea. Neuropeltis velutina is not present in this area and its specimens hitherto assigned to it are classified in a new species N. occidentalis. A key to and a synopsis of all African species is provided. The new species is illustrated and its distribution is mapped. Neuropeltis sanguinea from Angola (Cabinda) is newly synonymised under N. velutina.