FORMULATION AND INVITRO EVALUATION OF EFFERVESCENT FLOATING TABLETS OF DOMPERIDONE

The present study was aimed to formulate and evaluate floating tablets of Domperidone by direct compression method. Domperidone is a dopamine antagonist medication which is used to treat nausea and vomiting and certain gastrointestinal problems like gastroparesis (delayed gastric emptying). In this study, excipients like Eudragit RSPO, HPMC, Carbopol 974P, sodium bicarbonate and Citric acid were incorporated in a nine different concentrations (F1-F9) along with other excipients (Magnesium Stearate, Talc and Micro crystalline cellulose) to formulate floating tablets by direct compression method. Then all the nine formulations were evaluated for uniformity of weight, hardness, thickness, friability test, floating lag time, drug content and dissolution studies. The dissolution profile of trial-7 (formulation 7) was observed to be better than other formulations. In trial-7 Domperidone was formulated as a floating tablet by using Carbopol 974P (32.5 mg) as a matrix forming polymer and sodium bicarbonate (10 mg) as a gas generating agent. Trial-7 formulation showed a good dissolution profile for a controlled period of time which was noticed to be as 99.29 % at the end of 12th hour. Thus, it can be concluded that the floating drug delivery system of Domperidone using the appropriate polymers in right amount may enhance the activity of the drug by prolonging the gastric residence time or reducing the floating lag time.

Key words:  Domperidone, Eudragit RSPO, HPMC, Carbopol 974P and Floating Tablets.