FORMULATION DEVELOPMENT AND IN VITRO CHARACTERIZATION OF FAMOTIDINE SUSTAINED RELEASE MATRIX TABLETS

The aim of the present study was to develop sustained release formulation of Famotidine to maintain constant therapeutic levels of the drug for over 12 hrs. By using different ratios of synthetic polymers like HPMC K100M, Ethyl cellulose Natural polymer like Xanthan gum was employed as polymers. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that the formulation (F3) showed better and desired drug release pattern i.e., 96.61% in  24 hours. It contains the HPMC K100M 1:3 ratios as sustained release material. It followed Higuchi release kinetics mechanism.

Keywords: Famotidine, Sustained release tablets