Retrospective Evaluation of Child Cases Followed with the Prediagnosis of Crimean-Congo Hemorrhagic Fever
Authors/Creators
- 1. Etlik City Hospital, Pediatric Hematology Oncology Clinic, Ankara, Turkey
- 2. Gaziosmanpaşa University Department of Pediatrics, Tokat, Turkey
- 3. Department of Emergency Medicine, Ankara City Hospital, Ankara Yıldırım Beyazıt University, Ankara, Turkey
- 4. Ankara Research and Training Hospital, Department of Emergency, Ankara, Turkey
- 5. Royal Alexandra Hospital Glasgow, Department of Emergency, United Kingdom
Description
Aim: The aim of our study is to evaluate the clinical, demographic
and laboratory findings of the patients who were followed up
with the diagnosis of Crimean-Congo hemorrhagic fever (CCHF) in
Gaziosmanpaşa University Medical Faculty Child Health and Diseases
Service. This study was carried out with the aim of this study was to
observe the importance of early diagnosis, observing the effects of
the supportive treatment, documenting hospitalization time and the
complications during the treatment.
Material and Method: The study was carried out in a single center,
Gaziosmanpaşa University Faculty of Medicine, Pediatrics Service
in accordance with the Declaration of Helsinki Principles. Medical
records of patients who were followed up with a prediagnosis of CCHF
between January 2012 and July 2016 were retrospectively reviewed.
Epidemiological, demographic and clinical characteristics, laboratory
data, treatment methods and results of all cases were evaluated from
patient files.
Results: Between January 2012 and July 2016, a total of 100 patients
with CCHF were detected. 52 % of the patients came from rural areas.
The most applications were in April and June ( 69 % ) months. 100 %
of the patients had a history of contact with ticks. The main symptoms
and signs were fever (38%), haematological findings (34%), malaise
( 47 % ), abdominal pain (11 %), headache (25 %) and muscle pain
(44 %). At the time of admission to the hospital, 6 % of patients had
thrombocytopenia, 26 % had leukopenia, 26 % had elevated aspartate
aminotransferase (AST), 12 % had elevated alanine aminotransferase
(ALT), 44 % had elevated lactate dehydrogenase (LDH), 70 %
had elevated creatine phosphokinase (CPK), 8 % had prolonged
prothrombin time (PT), prolonged active partial thromboplastin time
(aPTT) in 28 % and elevated international normalised ratio (INR) in 13
%. All patients underwent liquid-electrolyte therapy for support, 5 %
aphasic platelet suspension, 13 % fresh frozen plasma, 12 % repeated
erythrocyte suspension, and 13 % received ribavirin treatment. All of
the patients who were included in the study were discharged with
recovery.
Conclusion: In conclusion, clinical manifestations of CCHF are similar
to adults in children and CCHF is more favorable in children. There is no
definitive proven treatment method yet, and most of the treatment is
supportive treatment.