Accompanying code for " Monitoring pump parameters to detect cardiac arrhythmia and major bleeding in LVAD patients: A proof-of-concept"

The number of patients on left ventricular assist device (LVAD) support increases due to the growing number of patients with end-stage heart failure and the limited number of donor hearts. Despite improving survival rates, patients frequently suffer from adverse events such as cardiac arrythmia and major bleeding. Telemonitoring is a potentially powerful tool to early detect deteriorations and may further improve outcome after LVAD implantation. Hence, we developed a personalized algorithm to remotely monitor HeartMate3 (HM3) pump parameters aiming to early detect unscheduled admissions due to. cardiac arrythmia and major bleeding. The source code of the algorithm made publicly available. The algorithm was optimized and tested retrospectively using HM3 power and flow data of 120 patients, including 29 admissions due to cardiac arrythmia and 14 admissions due to major bleeding. Using a true alarm window of 14 days prior to the admission date, the algorithm detected 59% and 79% of unscheduled admissions due to cardiac arrythmia and major bleeding, respectively, with a false alarm rate of 2%. 

Within this repository, you will discover the R code essential for implementing the personalized algorithm presented in the paper. It also encompasses simulated data, which serves as a means to assess and validate the algorithm's performance. Furthermore, a simple tutorial has been prepared to guide users on effectively utilizing the algorithm.

We suggest users to submit either their original or simulated data for testing the algorithm.