Absorption, Distribution, Metabolism and Elimination of Drugs, Factors Influencing Pharmacokinetics in Healthy Individuals
Authors/Creators
- 1. Assistant Professor, College of Veterinary Science, Korutla, PVNRTVU, Telengana, Hyderabad, India
- 2. Veterinay Doctor, College of veterinary science, Proddatur, Andhra Pradesh, India
- 3. Associate Professor, College of veterinary science, Proddatur, Andhra Pradesh, India
- 4. Staff, Indian Veterinary Research Institute (IVRI), Izathnagar, Barielly district, Uttar Pradesh, India
- 5. Assistant General Manager, Vaishnavi Bio pharma pvt. Ltd., Telangana, India
- 6. Assistant Professor, Contract Teaching Faculty, College of veterinary, science, Proddatur, Andhra Pradesh, India
Description
Pharmacokinetics is related to the study of drugs regarding their absorption, distribution, metabolism as well as elimination from the body. Absorption is the first stage in the pharmacokinetic process and plays a role in assessing the drugs bio availability as well as onset of action. Distribution is the second phase of pharmacokinetics and occurs after a drug is absorbed into the blood stream. The distribution process is affected by many factors namely the drugs physico chemical properties, blood flow to different tissues and the presence of binding proteins. Metabolism is related to the processing of the drugs by the body, along with their absorption, distribution, metabolism and elimination (ADME). Metabolism refers to the chemical modification of a drug, often through enzymatic reactions, to change it into metabolites that are more easily excreted. The main routes of excretion are renal (through urine), hepatic (through bile), pulmonary (through breath) and fecal (through feces). It is finally concluded that doctors can personalize modification patterns, ensuring that drugs are processed appropriately in the body of a healthy individual.
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References
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