ORGANOGERMANIUM COMPOUNDS: DESIGN, SYNTHESIS, LIGATION PROPERTIES AND OPPORTUNITY IN CHEMICAL BIOLOGY

Abstract: The field of organogermanium in chemistry becomes important as Germanium compounds have a low mammalian toxicity and show activity against certain bacteria, which makes them useful as chemotherapeutic agents. Consideration is given to the use of organogermanium compounds (OGCs) in the development of biologically active pharmaceuticals with distinct features and a variety of pharmacological effects, such as the Panaxel drug family and the Germavit mineral vitamin complex. New biologically active materials for medical technologies have been created based on OGC, including bandages, dental floss, and surgical sutures for retention. OGC's biological activity also enables its application in the fragrance and cosmetics sectors. The present review covers the design and synthesis of Organogermanium compounds along with their biological activities. The review provides an overview of the various synthesis techniques for the synthesis of Organogermanium compounds and the synthesized compounds are further characterized by using various spectroscopic techniques like NMR, IR, XRD, and UV Visible etc. The fully characterized compounds are further evaluated for their biological activities and all the compounds shows good biological activities like antimicrobial, cytotoxicity, antitumor etc.

Keywords: Antioxidant, Bacteria, Biological activities, Organogermanium and Pathogens.

Title: ORGANOGERMANIUM COMPOUNDS: DESIGN, SYNTHESIS, LIGATION PROPERTIES AND OPPORTUNITY IN CHEMICAL BIOLOGY

Author: Annu Devi, Mamta, Anita Phor, J.S. Phor, Ashu Chaudhary

International Journal of Recent Research in Physics and Chemical Sciences (IJRRPCS)

ISSN 2350-1030

Vol. 10, Issue 1, April 2023 - September 2023

Page No: 27-36

Paper Publications

Website: www.paperpublications.org

Published Date: 22-July-2023

DOI: https://doi.org/10.5281/zenodo.8174342

Paper Download Link (Source)

https://www.paperpublications.org/upload/book/ORGANOGERMANIUM%20COMPOUNDS-22072023-4.pdf