Korean Colorectal Cancer Cohort RNA-seq data set from Asan Medical Center
Authors/Creators
- 1. Korea Bioinformation Center (KOBIC), Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea
- 2. the Department of Surgery, Division of Colon and Rectal Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea
- 3. Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Republic of Korea
Description
This study presents a comprehensive molecular analysis of colorectal cancer (CRC) in Korean patients using RNA-sequencing data and clinical information. Key findings include significant differences in gene expression between tumor and normal tissues and identification of dysregulated pathways related to tumor progression. CRC samples were stratified into molecular subtypes, confirming their similarity to established CRC classifications. Immunological analysis highlighted distinguishing features between tumor and normal tissues, and some patients were found to be responsive to immunotherapy, especially those with microsatellite stable (MSS) tumors, who demonstrated a better prognosis. These insights enhance the understanding of CRC in Korean patients and support the use of RNA-seq data to inform cancer treatment and improve patient care.
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