Published July 19, 2023
| Version v1
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Shared metabolic shifts in endothelial cell in stroke and Alzheimer's disease revealed by integrated analysis
Description
In this study, we integrated single-cell sequencing datasets of ischemic stroke (IS), hemorrhagic stroke (HS) and AD models to construct metabolic flux profiles at single-cell levels. We discovered that the three disorders cause shared metabolic shifts in endothelial cells. These altered metabolic modules were mainly enriched in the transporter-related pathway and were predicted to potentially lead to a decrease in metabolites such as pyruvate and fumarate.
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