HISTOLOGICAL EXAMINATION OF WOUNDS TREATED WITH CRUDE LATEX OF Calotropis procera STEM

Abstract: Evaluation of wound healing activity of crude latex of Calotropis procera stem was investigated in this present study. Thirty (30) rats of both sexes were divided into six groups of five animals each, Group A (Control) was administered feeds and distilled water only; group B was treated with 0% Calotropis procera crude latex + 100% ointment ; group C was treated with 25% Calotropis procera crude latex + 75% ointment; group D was treated with 50% Calotropis  procera crude latex + 50% ointment; group E was treated with 75% Calotropis procera crude latex + 25% ointment and group F was treated with 100% Calotropis procera crude latex + 0% ointment. The results of histological examination showed that the wounds after 7 days treatment with crude latex of Calotropis procera stem exhibited marked dryness of wound edges with regeneration of healing tissue and the wound area was also considerably reduced. A near test of granulation tissue sections displayed faster tissue regeneration in the treated group compared to untreated group administered distilled water only. Also, there was marked infiltration of inflammatory cells, increased blood vessel formation and enhanced proliferation of fibroblasts in latex of Calotropis procera stem treated groups mostly group F which performed favourably and higher than the conventional ointment. The fresh crude latex of Calotropis procera stem showed practical wound healing activity which was attributed to its phytochemical constituents. The mechanism of action of wound healing property of latex of Calotropis procera and future research on internal wound healing like ulcer are recommended for further study.

Keywords: latex, ointment, wound, Calotropis procera, stem. 

Title: HISTOLOGICAL EXAMINATION OF WOUNDS TREATED WITH CRUDE LATEX OF Calotropis procera STEM

Author: Ajiboso, S.O., Enemali, M.O., Zaruwa, M,Z., Muhammed, B.Y.

International Journal of Recent Research in Life Sciences (IJRRLS)

ISSN 2349-7823

Vol. 10, Issue 3, July 2023 - September 2023

Page No: 9-18

Paper Publications

Website: www.paperpublications.org

Published Date: 15-July-2023

DOI: https://doi.org/10.5281/zenodo.8150360

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https://www.paperpublications.org/upload/book/HISTOLOGICAL%20EXAMINATION%20OF%20WOUNDS-15072023-5.pdf