Dataset for the project "LRRK2 as a novel pharmacological target for treatment of neurodegenerative diseases" (GR-2016-02362548)
Authors/Creators
- 1. Università degli Studi di Brescia; IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
Description
Dataset for the project "LRRK2 as a novel pharmacological target for treatment of neurodegenerative diseases" (GR-2016-02362548).
Aim 1:
Understanding whether LRRK2 mediates neuroinflammation triggered by PD and AD misfolded proteins using in vitro and in vivo models.
Aim 2:
Exploring whether and how LRRK2-related neuroinflammation affects hiPSC-derived neuronal function.
Aim 3:
Exploring whether hiPSC-derived neurons carrying LRRK2 mutation/variant are more vulnerable to neuroinflammation.
The present dataset contains the following folders:
1- Aim 1
- In vitro
- Attivazione infiammazione
- Generazione proteina amiloide
- LRRK2 infiammazione
- In vivo
- Generazione proteina amiloidi
- Infiammazione abeta
- Infiammazione asyn
- Microglia-Astrociti abeta
- Microglia-Astrociti asyn
2- Aim 2
- hiPSC Col RNASeq
- hiPSC DA RNASEq
- Neuroni colinergici
- Neuroni dopaminergici
3- Aim 3
- Gentotyping human cells
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