Published July 10, 2023 | Version v1
Dataset Open

Data for "Analysis of Wilms' tumor protein 1 specific TCR repertoire in AML patients uncovers higher diversity in patients in remission than in relapsed"

Description

This folder holds the data for the paper "Analysis of Wilms' tumor protein 1 specific TCR repertoire in AML patients uncovers higher diversity in patients in remission than in relapsed" (in submission) More information regarding this paper and the data is given in the GitHub repository (https://github.com/sgielis/WT1_TCR)

The raw folder contains all MiXCR files for the two studied WT1 epitopes and two VZV epitopes. The VZV epitopes were not taken into account in this paper, but were used to build VZV-specific TCRex models for another paper [in submission]. Since all TCRs for the 4 epitopes were sequences together, this data was used for quality control purposes as explained in the paper. Following 4 folders are present:

  • run1: TCR data from the first run for WT1-126, WT1-37 and IE62
  • run1_orf18: TCR data from the first run for ORF18
  • run2: WT1-37 data filtered on high and low threshold gating.
  • run 3: extra TCR data for WT1-126, WT1-37 aligned with MiXCR

 

Notes

This work was supported in part by research grants of the Special Research Fund of the University of Antwerp (Small Research Grants ID36379, BOF-KP2018 P.M. and ID41605, Concerted Research Action) and the Methusalem financing program of the Flemish Government to the Antwerp University, the Cellular Therapy Fund from the Antwerp University Hospital (UZA) and UZA Foundation (Belgium), iBOF Project "Modulating Immunity and the Microbiome for Effective CRC Immunotherapy" (MIMICRY) and the public utility foundation Stichting ME TO YOU (Belgium). D.F. was supported by the ''Cellular Immunotherapy'' grant from the Baillet Latour Fund (Belgium), and an Emmanuel van der Schueren fellowship from Kom op tegen Kanker (KotK, Belgium), followed by a DOCPRO PhD grant of the Special Research Fund (Grant MulTplex). S.G. and M.V. were supported by an SB fellowship from the FWO (S.G. grant 1S48819N, M.V. grant 1S24517N). E.B. and S.v.d.H. were supported via a clinical investigator fellowship from the Research Foundation-Flanders (FWO, Belgium) of B.O. (grant 1861219N). D.C.D. and H.D.R. were supported by grant G053518N from the FWO.

Files

raw.zip

Files (1.2 MB)

Name Size Download all
md5:5b8aca5d85f016c3a1ffedeb1a69989f
1.2 MB Preview Download