OPTIMIZATION OF TREATMENT METHODS IN EXCESSIVE HEMOLYTIC ANAEMIA

Currently, the main interest of scientists is to study the mechanism of development and treatment methods of hemolytic anemias (HC), which account for 5.3% of all blood system diseases and 11.5% of anemia cases in the world.[1]^,[2]. At the same time, the study of the mechanisms of erythrocyte breakdown, which provides natural tolerance in hemolytic anemias, and also leads to hemolytic processes as a result of the disruption of these mechanisms, is becoming more relevant.[3]^,[4]. Determining the mechanism of erythrocyte disintegration associated with the development of the iron metabolism system imbalance, antioxidant protection, lipid peroxidation and endogenous intoxication syndrome in experimental hemolytic anemias allows to develop new ways of their correction.

[1]Mentzer WC, Schrier SL Extrinsic nonimmune hemolytic anemias. In: Hoffman R, Benz EJ Jr., Silberstein LE, et al., eds. Hematology: Basic Principles and Practice. 7th ed. Philadelphia, Pa.: Elsevier; 2018:663–672.

[2]Onyeabo Ch., Achi K. Ngozi, Ekeleme-Egedigwe Chima A., Chidinma U. Ebere, Chidinma K. Okoro Haematological and biochemical studies on justicia carnea leaves extract in phenylhydrazine induced-anemia in albino rats// Acta Sci. Pol. Technol. Alimony. 16(2) 2017, 217–230.

[3]Paul S., Naaz S., Ghosh A., Mishra S., Chattopadhyay A. and Bandyopadhyay D. Melatonin chelates iron and binds directly with phenylhydrazine to provide protection against phenylhydrazine induced oxidative damage in red blood cells along with its antioxidant mechanisms: an in vitro study. Melatonin Research. 1, 1 (Dec. 2018), 1-20. doi.org/10.32794/mr11250001.

[4]Phillips J., Henderson AC / Hemolytic Anemia: Evaluation and Differential Diagnosis. Am Fam Physician. 2018 Sep 15;98(6):354-361.