Evaluation of Maternal Serum Amyloid A as a Biomarker for Preeclampsia

Evaluation of Maternal Serum Amyloid A as a Biomarker for Preeclampsia
                    Ola Hussain Ashoor El-Attabi^1*,  Hala Abdulghani Al-Rawi ²

^{1. M.B.Ch.B, Residents doctor at Al-Yarmouk Teaching Hospital, Iraqi council of Medical & Health Specialization, Baghdad, Iraq.
2 .F.I.C.M.S (OB&GYN), Assistant Professor, College of Medicine/Al-Mustansiriya University/ Al-Yarmouk Teaching Hospital, Iraqi council of Medical & Health 
    Specialization, Baghdad, Iraq.}
Background: In current years, there has been a significant improvement in the management of preeclampsia, which has led to a decrease in mortality and morbidity. The challenge lies in its early diagnosis, when there are no apparent clinical signs, serum amyloid-A might be expected to play a role in the early detection and evaluation of preeclampsia. Objective: To investigate and evaluate the maternal serum levels of Amyloid-A as a biomarker for the prediction of preeclampsia.

Patients and method: A case-control study carried at Department of Obstetrics and Gynecology/Al-Yarmouk Teaching Hospital. Methods: This study was conducted during the period from January 2021 to October 2021. A convenient sample of 90 pregnant women was enrolled and divided into two groups; Cases group (consisted of 45 pregnant women who presented with preeclampsia) and control group (consisted of 45 normotensive healthy pregnant women matched with the study group for age, body mass index and gestational age). The level of serum amyloid-A, blood urea, serum creatinine, aspartate aminotransferase, alanine aminotransferase, platelets count were measured.

Results: The level of Amyloid-A was significantly higher in the preeclampsia group than in the control group (P-value<0.001). According to the cut-off point of 12.25 (ng/dl), 51% of the participants had positive amyloid-A. There was a significant association between the results of Amyloid-A and the development of preeclampsia, the sensitivity and specificity were 95.6, 93.3, respectively (P-value<0.001). The level of Amyloid-A significantly correlated with the level of aspartate aminotransferase and alanine aminotransferase (P-value<0.001 for both).

Conclusion: There is significant association between the level of maternal serum amyloid-A and the development of preeclampsia in pregnancy.