EFFICACY OF INHALED BUDESONIDE IN TRANSIENTTACHYPNEA OF NEWBORN : A RANDOMISED CONTROL STUDY
Authors/Creators
- 1. Resident of Department of Paediatrics MVJ Medical College and Research Hospital Bengaluru.
- 2. Professor of Paediatrics,- MVJ Medical College And Research Hospital Bengaluru.
Description
Background And Objectives: Corticosteroids have a role in increasingthe reabsorption of lung fluids. Hence, this study wasconductedto assess efficacyandsafetyofinhaledBudesonideinreducingtheneedforrespiratorysupport,clinicalimprovement, time to reach full feeds and duration of hospital stay in neonates withTTN.
Materials And Methods: 100 Neonates(>35weeks), diagnosed as TTNwere included in study andrandomized into 2 groups-study and control groups. Allthe neonates were managed as per existing NICU protocol. Along with standardsupportivemanagementincludingrespiratorysupport,theyreceivedfollowingnebulizationwith6hoursand12hoursafterthat.
Intervention:
Studygroup:Budesonidenebulization(2ml=1000ug)
Controlgroup:Placebo(0.9%Normalsalinesolution2ml)
Baselinedemographicandclinicalprofile,clinicalparametersat4,12,24and48hoursafter intervention, requirement of respiratory support, duration of hospital stay andadverseeventswererecorded,comparedandanalyzedinbothgroups.
Results: Improvement in Budesonide group was significantly better in regard torespiratoryrate,Downescore(P<0.000),andoxygensaturation(P<0.000)at4hours,12 hours, 24 hours and 48hour. The total duration of mean respiratory support instudygroup(13.8hours)wassignificantlylowerthanplacebogroup(32.52hours)andwasstatisticallysignificant(p<0.000).TherewassignificantdifferenceindurationofNICUstay(2.50±1.055vs3.86±1.088days,p<0.05)andoccurrenceofnosocomialinfection among study and control group. No significant adverse events related tosteroidinhalationwereobserved.
Conclusion: The early inhaled corticosteroid (budesonide) in TTN improved theclinicalcourseofTTN,withreduceddurationofrespiratorysupportandhospitalstay,withoutanysignificantsideeffects. InconclusioninhaledbudesonidecanbeusedasaoptioninmanagementofTTNinlatepretermandtermneonates.