A REVIEW ON PHARMACEUTICAL NANOCRYSTALS

About 40% of drugs on the market have problems with poor solubility in water, and it has been found that 70% of the molecules in water are practically insoluble in water. Nanocrystals can be prepared by top-down, bottom-up and combinatorial methods. Many patented products such as Nanocrystals®, DissoCubes®, NANOEDGE® and SmartCrystals® are based on our plans. The reduction in size leads to instability of the nanocrystalline system and Austenitic maturation to occur. Nanosuspension can be converted to a steady state by performing various processes, such as freeze drying, spray drying, pelleting, and pelleting to prevent solid state particles from aggregating. These techniques are known for their scalability and continuous nanocrystal formation. Nanocrystals can be characterized using Scanning Electron Microscopy, Transmissive Electron Microscopy, Atomic Force Microscopy, Differential Scanning Calorimetry, Fourier Transform Infrared Spectroscopy, Powder X-ray Diffraction, and Photon Correlation Spectroscopy. One of the biggest advantages of nanocrystals is their wide range of applications such as oral administration, ocular administration, pulmonary administration, transdermal administration, intravenous administration and target (brain and tumour target).

KEYWORDS:  Nanocrystals, Ostwald ripening, Bioavailability, Pearl milling, Lyophilisation