The effect of atropine with different concentration (0.025% and 0.01%) on myopia programming

In recent decades, myopia is becoming an epidemic. This is proven by a steady increase in the number of this type of refractive error around the world. One of the commonly used drugs for myopia is 1% atropine. However, frequent use of this drug has several side effects. The purpose of this study is to examine the effectiveness of 0.025% and 0.01% atropine compared with placebo for a year. The study involved 62 (124 eyes) children and adolescents between 4 and 14 years old with myopia of at least -1.0 and astigmatism up to 2.5 diopters. Considering the progression of the controlled spherical equivalent and the increase in the axial length of the eye in a year, 0,01% atropine was the most effective of all the applied concentrations. The pupil size in photopic and mesopic conditions increased and the accommodative amplitude decreased by 1.71± 2.61D, 0.28± 3.4D and 0.32± 2.91D in the groups 0.025%, 0.01% atropine and placebo respectively (p≤0.01).