FORMULATION AND PHARMACOLOGICAL STUDY OF POLYHERBAL COMBINATION FOR THE TREATMENT OF GLOMERULONEPHRITIS.

The study revealed that the methanol and aqueous root extracts of polyherbal combination possess several potent phytoconstituents observed in the methanol extract showed the presence of carbohydrates, steroids, glycosides, coumarins, saponins, flavonoids, alkaloids, tannins and phenols approximately in all plants. Whereas proteins and anthraquinones were reported in few plants and none of the plant showed the presence of lipids. The aqueous extracts also showed the presence of carbohydrates, steroids, glycosides, saponins, flavonoids and tannins approximately in all plants. Whereas, coumarins, phenols and anthraquinones reported in few plants only and none of the plat showed the presence of proteins, lipids and alkaloids. The phytoconstituents are playing a significant role in restoring elevated biochemical parameters which affecting the normal biological function. Carbohydrate is theprimary source of energy play an important role in protecting blood vessels while protein plays a beneficial role in the maturation of nephron because of maintaining the levels of dyslipidemia and protects the damage of glomerular cells of the kidney as supported by The steroids are strengthening of nephron and protect the damage of glomerular cells in IgA nephropathy and may prevent the loss of kidney function as supported by Nisha, 2017[239], while glycosides maintain the cellular transport of sodium and potassium in kidney tissues, resulting in the enhancement of renal tubular function.

Keywords: Glomerulonephritis, phytoconstituents, Rheumatoid arthritis.