Published June 3, 2023
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Expression of Type IV Collagen in the Placenta in Undifferentiated Displasia Connecting Tissue
Authors/Creators
- 1. PHD, (Medicine), Associate Professor of the Department of Obstetrics and Gynecology of the 1Chuvash State University named after I. N. Ulyanov, address: 428034, 45 Moskovsky Avenue, Cheboksary, Russia.
- 2. MD, DSc., prof. – the Head physician of the 2State Budgetary Institution of Healthcare "City clinical hospital of Vinogradov V.V." of the Healthcare Department of Moscow, address: 117292, Vavilova street, 61, Moscow, Russia. MD, DSc., prof. of the Department of Obstetrics and Gynecology, 3Institute of Clinical Medicine of Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russian Federation (Sechenovskiy University). address: 119435, Bolshaya Pirogovskaya st., 2, building 4, Moscow, Russia
- 3. MD, DSc, prof., - Head of the educational and methodical office of the 1State Budgetary Institution of Healthcare "City clinical hospital of Vinogradov V.V." of the Moscow Healthcare Department, address: 117292, 61 Vavilova street, Moscow, Russia, Professor of the Department of Obstetrics and Gynecology of the Medical Institute of Continuing Education of the 2Federal State Budgetary Educational Institution of Higher Education «Russian Biotechnological University» (FSBEU HE "ROSBIOTEKH"), address: 125080, 11 Volokolamskoe highway, Moscow, Russia.
- 4. MD, DSc, - Head of the head of the gynecological department of the 2State Budgetary Institution of Healthcare "City clinical hospital of Vinogradov V.V." of the Moscow Healthcare Department, address: 117292, 61 Vavilova street, Moscow, Russia, Head of the Department of Obstetrics and Gynecology of the Medical Institute of Continuing Education of the 4Federal State Budgetary Educational Institution of Higher Education «Russian Biotechnological University» (FSBEU HE "ROSBIOTEKH"), address: 125080, 11 Volokolamskoe highway, Moscow, Russia
- 5. PHD (Medicine), Associate Professor of the Internal Medicine Department of the 1Federal State Budgetary Educational Institution of Higher Education "Chuvash State University named after I.N. Ulyanov", address: 428034, 45 Moskovsky Avenue, Cheboksary, Russia
- 6. PHD (Medicine), Associate Professor of the Department of Obstetrics and Gynecology of the 1Federal State Budgetary Educational Institution of Higher Education "Chuvash State University named after I.N. Ulyanov", address: 428034, 45 Moskovsky Avenue, Cheboksary, Russia
- 7. PHD (Medicine), Associate Professor of the Department of Medical Biology with a course in Microbiology and Virology of the 1Federal State Budgetary Educational Institution of Higher Education "Chuvash State University named after I.N. Ulyanov"; address: 428034, 45 Moskovsky Avenue, Cheboksary, Russia
- 8. PHD (Medicine), Associate Professor of the Department of Dermatovenereology with Hygiene Course of the 1Federal State Budgetary Educational Institution of Higher Education "Chuvash State University named after I.N. Ulyanov"; address: 428034, 45 Moskovsky Avenue, Cheboksary, Russia
- 9. PHD (Medicine), Associate Professor of the Department of Obstetrics and Gynecology of the 1Federal State Budgetary Educational Institution of Higher Education "Chuvash State University named after I.N. Ulyanov"; address: 428034, 45 Moskovsky Avenue, Cheboksary, Russia
Description
In the preparations of women in childbirth with undifferentiated connective tissue dysplasia, positive structures to type IV collagen were revealed. A pronounced immunopositive reaction (+++) was observed by us in the subendothelial layer of the vessels of the chorionic villi, the stroma of the villi and cells. The area of expression of type IV collagen in women in the control group was 1363.9 ± 14.9 μm2. The expression of type IV collagen significantly (p≤0.05) increased in women with connective tissue dysplasia syndrome - 3824.16 ± 16.9 μm2.