FORMULATION AND EVALUATION OF GASTRO RETENTIVE FLOATING TABLET USING RIVASTIGMINE TARTRATE

The present investigation was a successful attempt to develop gastro retentive floating tablet of Rivastigmine Tartrate in order to improve controlled release of drug. The formulation was effectively prepared using biocompatible polymer HPMC K4M and sodium alginate chosen in appropriate concentration with the drug. The gastro retentive floating tablet was preapared by direct compression method by applying 3² factorial designs. HPMC K4M (X1) and Sodium Alginate (X2) were selected as independent variables, and nine formulations were prepared in accordance with the experimental design. The prepared tablet was evaluated for different parameter such as wight variation, hardness, friability, floating time, drug content, in vitro dissoluation, swelling index and Dissolution data were analyse for kinetic model to study kinetic release of drug. From the evaluation of floating tablet of rivastigmine tartrate, F6 batch shown results were within limits and % CDR (98.559 ± 0.197) and buoyant up to 12 hours. Therefor, batch F6 was concluded as optimized formulation that could release drug in stomach at controlled release manner and prove to be potential candidate for safe and effective formulation for prolonged period of time.

Keywords: Rivastigmine tartrate, floating tablet, gastro-retentive, 3² factorial designs, Anti’alzheimer, dementia.