Half dose ChAdOx1 nCoV-19 vaccine was equivalent to full doses to reduce moderate and severe COVID-19 cases
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Leonardo J. Galvão-Lima1
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Nésio Fernandes de Medeiros Junior2
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Galileu S. Jesus1
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Antônio H. F. Morais1
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Geyson J. P. Caldeira-Silva1
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João Paulo Q. Santos1
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Marcella A. Rocha1
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Marquiony M. Santos1
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Pierre A. Freire1
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Rodrigo D. Silva1
- Maria da Penha Gomes Gouvea3
- Lauro Ferreira Pinto Neto4
- Carla Magda Allan Santos Rodrigues5
- Andréa Teixeira-Carvalho6
- Olindo Assis Martins-Filho6
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Valéria Valim3
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Ricardo A. M. Valentim1
- 1. Laboratory of Technological Innovation in Health (LAIS), Hospital Universitário Onofre Lopes, Federal University of Rio Grande do Norte (UFRN), Natal 59078-970, Brazil
- 2. Programa de Pós Graduação em Saúde Coletiva (PPGSC), Universidade Federal do Espírito Santo, Vitória, Brazil
- 3. Programa de Pós Graduação em Saúde Coletiva (PPGSC), Universidade Federal do Espírito Santo, Vitória, Brazil; Hospital Universitário Cassiano Antônio Moraes [HUCAM-UFES/ Empresa de Serviços Hospitalares (EBSERH)
- 4. Escola Superior de Ciências da Santa Casa de Misericórdia de Vitória (EMESCAM), Vitória, Brazil
- 5. Pan-American Heath Organization Consultant
- 6. Grupo Integrado de Pesquisas em Biomarcadores, Instituto René Rachou, Fundação Oswaldo Cruz (FIOCRUZ-Minas), Belo Horizonte, Brazil
Description
Data Dictionary
| Column | Description | Type |
| Main ID | A unique and primary identification assigned to each individual. | Integer |
| Study ID | A specific research identification assigned to each patient. | String |
| Gender | The biological sex of the patient, which can be male or female (M or F). | String |
| Severity | A measure of the severity of the illness. 1- not infected 2- hospitalized 3- hospitalized ICU | Integer |
| Age | The age of the patient, usually in completed years. | Integer |
| Age_group | A category in which the patient's age is grouped, age ranges like 25-34 years or 45-54 years, etc. | String |
| Length_of_hospital_stay | The amount of time the participant spent hospitalized in days. | Integer |
| Hospitalization_and_outcome | Information about the participant's hospitalization and the outcome of the hospitalization. | Integer |
| Outcome | The outcome of the patient, whether there was death or not. | String |
| Before_d1 | Information about the patient's condition before the first dose of the vaccine. | Float |
| Severity_before | The measure of the severity of the participant's condition before the first dose of the vaccine. | Float |
| t_hospitalized_before | The amount of time the participant spent hospitalized before the first dose of the vaccine. | Float |
| time_hospitalization_before | The total amount of time the participant spent hospitalized in intensive care unit (ICU) before the first dose of the vaccine. | Float |
| Between_d1_d2 | Information about the patient's condition between dose 1 and dose 2 of the vaccine. | Float |
| Severity_between | The measure of the severity of the patient's condition between dose 1 and dose 2 of the vaccine. | Float |
| t_hospitalized_between | The amount of time the patient spent hospitalized between dose 1 and dose 2 of the vaccine. | Float |
| time_hospitalization_between | The total amount of time the patient spent hospitalized in intensive care unit (ICU) between dose 1 and dose 2 of the vaccine. | Float |
| After_d2 | Information about the patient's condition after dose 2 of the vaccine. | Float |
| Severity_after | The measure of the severity of the patient's condition after dose 2 of the vaccine. | Float |
| t_hospitalized_after | The amount of time the patient spent hospitalized after dose 2 of the vaccine. | Float |
| time_hospitalization_after | The total amount of time the patient spent hospitalized in intensive care unit (ICU) after dose 2 of the vaccine. | Float |
| Date_of_death | The date on which the patient died, if applicable. | Date |
| Immunization | Information about the patient's immunization for example HD - Half Dose and FD - Full Dose | String |
| Comorbidity | Whether the patient has any pre-existing medical conditions or not. | String |
This database contains information about the administration of the ChAdOx1 nCoV-19 vaccine in half doses and its equivalence in reducing moderate and severe cases of COVID-19 compared to full doses.
The ChAdOx1 nCoV-19 vaccine is developed to prevent infection by the SARS-CoV-2 virus, which causes COVID-19. The study analyzed the efficacy of administering the vaccine in half doses compared to full doses. The objective was to evaluate if the half dose would be as effective as the full dose in reducing moderate and severe cases of the disease.
Through this database, it is possible to analyze and assess the effectiveness of administering the ChAdOx1 nCoV-19 vaccine in half doses, as well as comparing it to the use of full doses. This information can be used by researchers, healthcare professionals, and authorities responsible for vaccination policies to support decisions and recommendations related to COVID-19 immunization.