Identification of genetic markers associated with clinical response of ketose treatment in Holstein cows

Additional File 1- Table S1. Mean and standard deviations of blood BHB concentration (mmol/L) for groups of cows classified as Chronic, Cured, Recurrent, and Severe considering their responses to the administration of propylene glycol and 50% dextrose to control hyperketonemia between 1st and 4nd week of lactation.

Additional File 2- Spreadsheet S1. List of genes, SNP and their functional consequences associated with ketosis identified through Cured vs Resistant contrast, Spreadsheet S2. List of genes, SNP and their functional consequences associated with ketosis identified through Severe vs Resistant contrast. Spreadsheet S3. List of genes, SNP and their functional consequences associated with ketosis identified through Chronic vs Resistant contrast, Spreadsheet S4. List of genes, SNP and their functional consequences associated with ketosis identified through Recurrent vs Resistant contrast.

Additional File 3- Spreadsheet S1. Pathways associated with genes identified to Cured vs Resitant contrast, Spreadsheet S2. Pathways associated with genes identified to Severe vs Resitant contrast, Spreadsheet S3. Pathways associated with genes identified to Chronic vs Resitant contrast, Spreadsheet S4. Pathways associated with genes identified to Recurrent vs Resitant contrast, Spreadsheet S6. Pathways associated with genes set identified among 4 analyzed contrasts (Cured, Severe, Chronic and Recurrent compared with Resistant, respectively), Spreadsheet S7. Protein Interaction network associated with genes set identified among 4 analyzed contrasts (Cured, Severe, Chronic and Recurrent compared with Resistant, respectively).

Additional File 4- Spreadsheet S1. Go terms and QTL associated with genes and SNPs related to ketosis identified through Cured vs Resistant contrast analysis, Spreadsheet S2. Go terms and QTL associated with genes and SNPs related to ketosis identified through Severe vs Resistant contrast, Spreadsheet S3. Go terms and QTL associated with genes and SNPs related to ketosis identified through Chronic vs Resistant contrast, Spreadsheet S4. Go terms and QTL associated with genes and SNPs related to ketosis identified through Recurrent vs Resistant contrast.