The Covid-19 Therapy

Introduction

Coronavirus is causing health, economic, and social crisis all over the world. If it is not stopped soon in this way, otherwise it is feared that it will kill tens of thousands of people and degrade all humanity to a severe and prolonged recession.

For the time being, the war in Covid 19 is mainly conducted through an effort to isolate people and prevent further adherence and by providing supportive care (especially the provision of fluids and oxygen) to those who have become ill and have respiratory distress. It is noteworthy: the infectious agents that can cause severe symptoms of the disease are mainly elderly and patients suffering from background diseases such as diabetes, cardiovascular diseases. For example, are high blood pressure and respiratory diseases such as asthma and Chronic Obstructive Pulmonary Disease (COPD). However, reports of mortality also obtained in young patients who were without risk factors and no background disease.

At the same time, there is a widespread effort in the world to develop both a vaccine for the disease and to find drugs that will cure patients. The effort in the field of medicine is dealing with mainly two: an effort to develop new drugs for the disease and an attempt to test existing drugs that may also be effective in the treatment of Corona-illness [1].

In the context of drugs, the public raises other questions: Can the drug treatment that many people receive for other non-corona problems aggravate the c Covid 19? Are there any particular recommendations for patients who consume medication regularly?

To date, there is no effective anti-coronary drug treatment, but the efficacy of existing drugs - some on the shelf - that are being used to treat other diseases is being investigated. Information on the efficacy of these drugs for the treatment of Covid 19 comes mainly from laboratory studies, but also from human clinical studies.

People with pre-existing heart disease are more at risk for severe cardiovascular and respiratory complications from COVID-19. Similarly, research has shown that influenza virus infection poses a more serious threat to people with heart disease than those without heart problems. Studies have also shown that respiratory infections like the flu can actually trigger heart attacks.

People with previously undiagnosed heart disease may present with quiet heart symptoms that were previously not obscured by the viral infection. In people with preexisting cardiovascular obstruction, infection, fever, and inflammation can undermine the stability of asymptomatic lipid plaque that previously existed in the heart vessels. Heat and inflammation also make the blood more prone to blood clotting, interfering with the body’s ability to dissolve blood clots - a one-two punch similar to gasoline injection on the coals of the wind [2].

Health officials from WHO have noted that Gilead’s remdesivir has demonstrated efficacy in treating the coronavirus infection.Health officials from WHO have noted that Gilead’s remdesivir has demonstrated efficacy in treating the coronavirus infection.

Remdesivir is a broad spectrum antiviral drug originally intended for Ebola. Researchers have found that remdesivir is most effective in fighting the new coronavirus. This treatment has not yet been approved in humans, but two clinical trials of this drug have been implemented in China. One clinical trial was also recently approved by the FDA in the United States.Chloroquine.

WASHINGTON - The US is fast-tracking the anti-malarial drug chloroquine for use as a treatment against the new coronavirus, US So said President Donald Trump on Thursday.

Trump told reporters that “we can get this drug almost immediate, and that’s where the FDA [Food and Drug Administration] was so big”[3].

Doctors can also use a number of different treatments to limit the immune system’s response to viruses, such as fever and inflammation, which can sometimes cause more harm to the patient than the virus itself. Anti-inflammatory drugs such as corticosteroids and chloroquine are most commonly used to reduce these symptoms. Chloroquine, a widely-used anti-malarial and autoimmune disease drug, has recently been reported as a potential broad spectrum antiviral drug.

Chloroquine is known to block virus infection by increasing endosomal pH required for virus/ cell fusion, as well as interfering with the glycosylation of cellular receptors of SARS-CoV [4-7].

“Chloroquine, a relatively safe, effective, and inexpensive drug used to treat many human diseases, including malaria, embiosis, and human immunodeficiency virus, is effective in inhibiting infection and spread of SARS CoV in cell culture. Post-infection offers possible preventative and therapeutic use.”

Chloroquine is a drug used to fight malaria and autoimmune diseases. It has been in use for over 70 years as a source material and is considered to be safe. Researchers have found that this drug is effective in fighting the SARS-CoV-2 virus in in vitro studies. At least 10 close-source clinical studies are currently examining the potential use of chloroquine as an option to fight the new coronavirus (Figure 1).