ANTIMICROBIAL SUSCEPTIBILITY PATTERN OF STAPHYLOCOCCUS AUREUS ISOLATED FROM VARIOUS CLINICAL SAMPLES IN A TERTIARY CARE HOSPITAL
- 1. DepartmentofMicrobiology,MGMMedicalCollegeandHospital,Aurangabad431003(Maharashtra)India.
Description
Background: Staphylococcusaureusisanosocomialpathogen,causinghighmorbidityandmortality.TheprevalenceofMRSAinfectionandthesusceptibilitypatternofStaphylococcusaureusvarieswiththeregion. WiththisbackgroundpresentstudywasundertakentodeterminetheprevalenceofstaphylococcusaureusandMethicillin-ResistantStaphylococcusaureus(MRSA)isolatesfromvariousclinicalsamplesandtheirantimicrobialsusceptibilitypatterninatertiarycarehospital.
MaterialsandMethods: Inthisretrospectivestudy,atotalof240isolatesofStaphylococcusaureuswascollectedfromaclinicalspecimen,betweenJune2021toMay2022intheDepartmentofMicrobiology,MGMMedicalCollegeandHospital,Aurangabad.StaphylococcusaureuswasidentifiedandtheirantibioticsusceptibilitytestingwasdeterminedbyusingVitek2compactsystemanddatawereanalyzed.
Result: Inourstudytotalof240StaphylococcusaureuswereisolatedandtheprevalenceofMSSAwas27.5%andtheprevalenceofMRSAwas72.5%fromvariousclinicalsamples. Outof240Staphylococcusaureusisolates,116(48.33%)wereresistanttoBenzylpenicillin,followedbyCiprofloxacin212(88.33%),Levofloxacin212(88.33%),Erythromycin154(64.17%),Clindamycin122(50.83%),Trimethoprim/Sulfamethoxazole120(50.00%),Gentamicin56(23.33%),Rifampicin15(6.25%)andTigecycline6(2.50%).
Conclusion: AhighprevalenceofMRSA(72.50%)wasobservedinourregion.ThemosteffectiveantibioticsforthetreatmentofMRSAwereLinezolid,Vancomycin,Teicoplanin,andTetracycline.TheseantibioticsshouldbekeptreservedforthetreatmentofMRSAinfection. Regularsurveillanceofhospital-associatedinfectionsisrequiredforassessingthetrendsintheantibioticresistanceofpathogensforstrengtheningthecontrolmeasurestopreventthespreadandreducetheemergenceofmultidrug-resistantMRSAinfections.
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