SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF CARBONYL DERIVATIVES OF ADENINE

Objective: In this study, a variety of adenine semicarbazide derivatives were created using adenine as a starting material followed by synthesis of their semicarbazone derivatives.

Methods: The antibacterial activity was assessed using a cup-plate method. Analgesic, anticonvulsant activity, and neurotoxicity of the compounds were assessed using a model of chemically induced convulsions; acetic acid induced writhing response model and the rotarod test on male albino mice. Results: The compounds AA2, AA3, AA4, AA5 and AA10 were found to be good peripheral analgesics showing % analgesic activity 67, 55.5, 54.1, 47.5 and 88.4% respectively & compound AA10 was the most active among all the derivatives tested for the central analgesic activity. AA3, AA7 and AA10 were found to be exhibiting good antibacterial activity. The findings showed that the compounds 2-(2-oxoindolin-3-ylidene)-N-(9H-purin-6-yl) hydrazinecarboxamide (AA3) and 2-((E)-3-phenylallylidene)-N-(9H-purin-6-yl) hydrazinecarboxamide (AA10) were the most active, powerful, and least poisonous ones.

Conclusion: The present work involves pharmacological evaluation of adenine derivatives. The outcomes obtained from the work are significant for further research concentrating on examining prospective options for treatments for epilepsy.

Keywords: Epilepsy, Anticonvulsant, Analgesic, Adenine, antiepileptic.