Autoimmune Suppression of Immune Response to a Certain Antigen

The article concerns studies on suppression of immune response to a certain antigen with application of auto-
logic anti-idiotypic antibodies. The experiments were carried out on the male rabbits of "Shinshilla" species.
The animals were immunized with bovine serum albumin (BSA), immunoglobulins were precipitated from
the blood, anti-BSA polyclonal antibodies were purified using the technique of immune affinity chromatog-
raphy, they were digested with the enzyme (pepsin) and F(ab)2-fragments of the anti-BSA antibodies were
purified using the technique of gel-chromatography. Immunization of the rabbits with F(ab),-fragments of
the anti-BSA autologic antibodies led to significant downregulation of the earlier induced immune response
to BSA.