Raw ILLUMINA NGS data from study on Mouse virulence of European type III and type II x III-recombinant natural clones of Toxoplasma gondii is not always linked to the ROP18 and ROP5 genotype

Published April 21, 2023 | Version 1

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Whole genome sequences of naturally recombinant European type III and type II x III clones were analyzed
While two of the type II x III recombinants showed an intermediate mouse virulence, a type III clone was highly virulent
Of the three highly virulent clones, only two showed a virulent ROP18-ROP5 allele combination
The mouse virulent type III clone without virulent ROP18-ROP5 allele combination showed the highest level of ROP5 mRNA expression
Two genetically similar clones showed apparent differences in virulence and corresponding IL-12 mRNA expression in infected macrophages

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European Commission
One Health EJP - Promoting One Health in Europe through joint actions on foodborne zoonoses, antimicrobial resistance and emerging microbiological hazards. 773830