Rat gadoxetate MRI signal dataset for the IMI-WP2-TRISTAN Reproducibility study

Dataset to accompany the manuscript "Assessment of hepatic transporter function in rats using dynamic gadoxetate-enhanced MRI: A reproducibility study" by Ebony R. Gunwhy, Claudia Green, Iina Laitinen, Sirisha Tadimalla, Steven Sourbron, Paul D. Hockings, Gunnar Schütz, J. Gerry Kenna, John C. Waterton, and Catherine D. G. Hines (referred to as the 'Reproducibility' study).

data.zip

After extracting the contents within the data.zip folder, the MRI signal data acquired in this study are provided in csv format and can be found inside the data/Reproducibility/01_signals subfolder. Each csv file contains the liver and spleen region of interest (ROI) time curve data for a single rat from a specific substudy and day, after administration of the test compound of interest.

The corresponding filename for each file is formatted as a string containing study descriptors (metadata) separated by underscores, i.e., filename = substudy_compound_site_RatNumber_dayNumber_dataType, e.g., 1_Rifampicin_D_Rat5_2_Signals.

results.zip

The results and figures relating to this manuscript were created using the outputs contained in results/Reproducibility/2023-04-17.

01_model_ouputs contains all outputs generated as a result of the tracer kinetic model fitting. Within this, plotted signal time curves for each acquistion per rat may be found in figures/per_rat, while average deltaR1 curves per substudy may be found in figures/per_substudy. All estimated parameter variables from the fitting are stored in all_parameters.csv. The folder relaxation_rates_and_signals contains the fitted MRI signal data in a similar format to the original csv data in data/01_signals. Additional columns have been included showing the MRI signals converted to R1. fit_errors.txt contains an ID list for any computational fitting errors found during quality control of the tracer kinetic modelling.

02_analyses contains results of the statistical analysis performed on the tracer kinetic modelling output. These are summarised in tabular csv format within the repeatability/ and reproducibility/ folders, while graphical distributions are provided within the figures/ folder. Summary results for benchmark values and from the mixed ANOVA are also provided in benchmarks.csv and mixed_anova.csv, respectively. Please see the manuscript for further details on these results.