FORUMATION AND EVALUATION OF ORAL DISINTEGRATING TABLETS OF SELEGILINE

Difficulty in swallowing is common among all age groups especially elderly and pediatrics. Oral disintegrating tablets may constitute and innovative dosage form that overcome the problem of swallowing and provide a quick onset of action. This study was aimed to formulate and evaluate an orally disintegrate tablet (ODT) containing Selegiline while using Superdisintegrants. Oral disintegrate tablets were prepared by direct compression by using Superdisintegrants Primojel, Ac-di-Sol and Polyplasdone XL10. The prepared tablets were evaluated for hardness, friability, thickness, drug content uniformity. According to the results of optimized batches the concentration of Superdisintegrant were given rapid disintegration in 21 seconds which showed 98.12 % drug release within 45 minutes. Primojel, gives a rapid disintegration and when used in formulation of ODT.

Key Words: Selegiline, Primojel, Ac-di-Sol, Polyplasdone XL10 and Oral Disintegrating Tablets.