Rational Modification of Human Gut Microbial Metabolites by Dietary Resistant Starch in Patients After Allogeneic Hematopoietic Stem Cell Transplantation: A Prospective Feasibility Study

Riwes, Mary; Golob, Jonathan L; Magenau, John; Lyssiotis, Costas; Shan, Mengrou; Dick, Gregory; Braun, Thomas; Schmidt, Tom; Pawarode, Attaphol; Anand, Sarah; Ghosh, Monalisa; Maciejewski, John; King, Darren; Choi, Sung; Yanik, Gregory; Geer, Marcus; Tewari, Muneesh; Reddy, Pavan

doi:10.5281/zenodo.7807174

Published April 6, 2023 | Version v1

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Rational Modification of Human Gut Microbial Metabolites by Dietary Resistant Starch in Patients After Allogeneic Hematopoietic Stem Cell Transplantation: A Prospective Feasibility Study

We conducted a prospective longitudinal feasibility study in patients undergoing allo-HCT for hematological malignancies to test the hypothesis that defined and consistent administration of resistant starch will rationally modify intestinal microbiota dependent metabolites, particularly the short chain fatty acids (SCFA), such as butyrate. Ten adults undergoing human leukocyte antigen-matched, related-donor myeloablative allo-HCT were enrolled and received resistant potato starch (RPS) daily from day -7 to day 100 after allo-HCT.

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Plasma_metabolites.csv

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Plasma_metabolites.csv md5:11e2e37611743c3f536e49fd87764033	95.5 kB	Preview Download
Plasma_SCFA.csv md5:e1edbfc78c97f56c8ad343c1890e6bfa	10.2 kB	Preview Download
SCFA_stool.csv md5:9879384e3ac939a462902e3eee13768a	3.9 kB	Preview Download

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Rational Modification of Human Gut Microbial Metabolites by Dietary Resistant Starch in Patients After Allogeneic Hematopoietic Stem Cell Transplantation: A Prospective Feasibility Study

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Plasma_metabolites.csv

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