Published March 28, 2023
| Version v1
Dataset
Open
Dopamine transporter and synaptic vesicle sorting defects underlie auxilin-associated Parkinson's disease
Creators
- 1. Yale University, USA
- 2. Columbia University, USA
- 3. National Institutes of Health, USA
Description
Auxilin participates in clathrin uncoating to facilitate presynaptic endocytosis. Loss-of-function mutations of auxilin (PARK19) cause Parkinson’s disease. Using auxilin KO mice, Vidyadhara et al. (2023) show that synaptic vesicle sorting deficits, cytoplasmic dopamine accumulation, dopamine transporter mistrafficking, and synaptic autophagic overload may lead to pathogenesis of Parkinson’s disease in PARK19 patients. This file contains the data set used to generate all the main figures.
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Additional details
Related works
- Is source of
- Journal article: 10.1016/j.celrep.2023.112231 (DOI)
Funding
- Aligning Science Across Parkinson's
- Adaptive immunity in the etiology and progression of Parkinson’s disease ASAP-000375
- Aligning Science Across Parkinson's
- Tracing the Origin and Progression of Parkinson’s Disease through the Neuro-Immune Interactome ASAP-000529